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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۹۸-۹۸
عنوان فارسی P۴۸: Self-Assembling Peptide Nanostructures as a Good Scaffold for Treatment of Spinal Cord Injury
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P48: Self-Assembling Peptide Nanostructures as a Good Scaffold for Treatment of Spinal Cord Injury
چکیده انگلیسی مقاله To date, various approaches have been used in attempt to treat spinal cord injury (SCI) but there is no definite treatment for repair of the damaged tissue. It is well known that SCI results in a loss of neural tissues and formation of cystic cavities that inhibit regeneration of axons. Tissue engineering, in which cells, signals and scaffolds are combined, is one of the most promising areas of research due to its potential to regenerate damaged or lost tissues. Peptide nanostructures formed through molecular self-assembly are increasingly important for material science and regenerative medicine. Peptide self-assembly allows the design and fabrication of supramolecular architectures at nanoscale. Self-assembling peptides (SAPs) have been developed under physiological conditions that can form 3 dimension structures of nanofibers. SAPs are amenable to injection due to their water solubility and exhibit dramatic morphology changes immediately after injection due to the addition of salts from the cerebro- spinal fluid. SAPs can reduce the glial reaction and support the host cells to migrate and fill the cavity. In addition, SAPs provide a 3 dimensional environment for axonal elongation and angiogenesis.With application of the biocompatible, non-toxic and biodegradable SAPs in SCI, we can help the injured tissue to repair and reconstruct.
کلیدواژه‌های انگلیسی مقاله SAPs, Scaffold, Spinal Cord Injury
نویسندگان مقاله سجاد سحاب نگاه | sajad sahab negah
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

هادی علیقلی | hadi aligholi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

مصطفی مدرس موسوی | mostafa modarres mousavi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

ذبیح اله خاکسار | zabihollah khaksar
histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

هادی کاظمی | hadi kazemi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. pediatric department, shahed university, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

شاهین محمد صادقی | shahin mohammad sadeghi
department of plastic and reconstructive surgery, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-445&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332295.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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