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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۱۰۱-۱۰۱
عنوان فارسی P۵۱: Thermogel Nanofiber Induces Human Endometrial-Derived Stromal Cells to Neural Differentiation and Improves Motor Dysfunction Following Spinal Cord Injury
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P51: Thermogel Nanofiber Induces Human Endometrial-Derived Stromal Cells to Neural Differentiation and Improves Motor Dysfunction Following Spinal Cord Injury
چکیده انگلیسی مقاله Although spinal cord injury (SCI) is one of the most common injuries after a road accident, there is no definite treatment for it. In this regard, nanotechnology has focused to retrieve damaged tissue function by designing of a biomaterial as a mimicking extracellular matrix to reduce inflammation, scar and lactate dehydrogenase, to fill the cyst and improve the graft integration, cell proliferation and differentiation in site of injury. In this study, the neuronal differentiation potential of termogel nanofiberous Matrigel as a self-assembling nanofiber was investigated. Human endometrial-derived stromal cells (hENSCs) were isolated and encapsulated into nanofiberoustermogel and cell viability and cell membrane damage were assessed. Encapsulated hENSCs into Matrigel were treated with neural differentiation medium for 21 days, and then neural genes and protein markers were analyzed using real time-PCR and immunocytochemistry assays. In addition, Matrigel was implanted into an animal model of SCI and followed up for 45 days using Basso-Beattie-Bresnahan (BBB) test. Our results showed higher cell viability and lower cell membrane damage in cells encapsulated into the nanofiber as compared to 2D cell culture. Also, it was seen neural differentiation in the level of genes and proteins and significant improvement in motor function of the injured animals. Matrigel with the ability of neural induction and motor function improvement could be as an applied scaffold in tissue engineering for SCI.
کلیدواژه‌های انگلیسی مقاله Matrigel , Nanofiber, Spinal Cord Injury
نویسندگان مقاله شیما توکل | shima tavakol
a. department of medical nanotechnology, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran. b. student’s scientific research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

هادی علیقلی | hadi aligholi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. department of neurosciences, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی گرجی | ali gorji
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. institute for physiologie i, westfälischewilhelms-universitätmünster, germany.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

آرزو اسحق آبادی | arezou eshaghabadi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

مهدی رضایت | mehdi rezayat
a. department of medical nanotechnology, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran. b. department of toxicology and pharmacology, school of pharmacy, pharmaceutical sciences branch, islamic azad university iaups , tehran, iran. c. department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

جعفر ai | jafar ai
a. department of tissue engineering, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran. b. brain and spinal injury research center, imam hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-448&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332298.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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