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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۱۲۶-۱۲۶
عنوان فارسی P۷۶: The Neuroprotective Roles of NMDA Receptors Antagonist Against with Lesion in Central Nucleus of Amygdala
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی P76: The Neuroprotective Roles of NMDA Receptors Antagonist Against with Lesion in Central Nucleus of Amygdala
چکیده انگلیسی مقاله The N-Methyl-D-aspartic acid (NMDA) receptor is one of the specific types of ionotropic receptors which lied to glutaminergic system. It has been widely accepted that NMDA receptor neurons promote anxiety, in humans as well as in animal models. However, in the previous study seems inhibiting of this receptors decreased the protective role in neural cell. Demonstration of NMDA receptor activity had neurodegeneration effect. The hypothesis of this study based on evaluated neuroprotectivity effect of NMDA receptor inhibition in the central nucleus of the amygdala (CeA) which have role in anxiety. In this study, we confirm that NMDA antagonist (MK801) is neuroprotective when CeA had confronted regional electrical lesion. Kindling of amygdala by electrical lesion which presented by stimulation of the CeA area after microinjection of MK801 (0.5 and 0.75 µg/kg) in the kindling area is may indicate neuroprotection from secondary injury. It seems the rats were confronted electrical lesion indicated specific decreases in the percentage of open arm time and percentage of open arm entries in elevated plus maze. However, in histopathological study, the mean of dark neurons of CeA in the MK801 group was less than lesion group. We concluded that inhibited of NMDA receptors in CeA neurons may contribute to induced neuroprotection by electrical lesion.
کلیدواژه‌های انگلیسی مقاله NMDA receptor, Neurodegenerative, Dark Neuron
نویسندگان مقاله میلاد احمدی | milad ahmadi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. faculty of veterinary medicine, islamic azad university, karaj branch, karaj, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

آزاده سجادیان | azadeh sajadian
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

هادی علیقلی | hadi aligholi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. department of neurosciences, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بابک خدایی | babak khodaie
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

احمدعلی لطفی نیا | ahmad ali lotfinia
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

محمود لطفی نیا | mahmoud lotfinia
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-474&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332323.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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