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Research Journal of Pharmacognosy، جلد ۴، شماره ۲، صفحات ۴۵-۵۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of hydroalcoholic extract of Pistacia vera on pentylenetetrazole-induced kindling in rat
چکیده انگلیسی مقاله Background and objectives: Most antiepileptic drugs that are commonly being used in the clinic have a wide range of unwanted side effects; while some species of pistachioshave been used in the traditional medicine to treat epilepsy. The aim of the present study was to investigate the anticonvulsant effects of the hydroalcoholic extract of Pistacia vera L. in pentylenetetrazole (PTZ)-induced chemical kindling. Methods: this study was carried out on 40 male Wistar rats. Chemical kindling was induced by intraperitoneal administration of PTZ (40 mg/kg) on every alternate day (30 days). The hydroalcoholic extract of P. vera (50 and 100 mg/kg) were administered orally every day (30 days). In days which animals received both PTZ and extract, PTZ was injected 30 min after extract administration. Convulsive behavior was observed for 30 min after PTZ injection and scored according to racine scale. Diazepam was used as the reference anticonvulsant drug. Results: Pretreatment with 50 and 100 mg/kg of P. vera extract decreased seizure scores, stage 4 latency and stage 5 duration compared to the control group. The anti-epileptic effects of P. vera extract were comparable to diazepam. Conclusion: The present findings demonstrated that the hydroalcoholic extract of P. vera may inhibit the development of seizure behavior following chronic PTZ-induced model of epilepsy in rats.
کلیدواژه‌های انگلیسی مقاله pentylenetetrazole,Pistacia vera,rat,seizure
نویسندگان مقاله f فاتحی |
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

i فاطمی |
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran. physiology-pharmacology department, rafsanjan university of medical sciences, rafsanjan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

a شمسی زاده |
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran. physiology-pharmacology department, rafsanjan university of medical sciences, rafsanjan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

e حکیمی زاده |
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

gh بازماندگان |
department of pharmacology, faculty of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

f خواجه حسنی |
department of radiology, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

m رحمانی |
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran. physiology-pharmacology department, rafsanjan university of medical sciences, rafsanjan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_44257_f8d8c74f666df7c845b9b09d2eaeb41e.pdf
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