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Journal of Medical Microbiology and Infectious Diseases، جلد ۳، شماره ۳، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Molecular Epidemiology of HIV-1 in Afghanistan, Iran, and Pakistan
چکیده انگلیسی مقاله We conducted this study to obtain a comprehensive picture of molecular epidemiology of HIV-1 in three neighboring countries, i.e. Afghanistan, Iran, and Pakistan as a basis for discussing possible hypothesis regarding between-country virus transmission. Our results showed that subtype composition differs between these countries with more variation in Pakistan than Iran and Afghanistan. The CRF35-AD clade was predominant in Afghanistan and Iran while the A1 subtype was predominant in Pakistan. HIV-1 sequences obtained from Pakistan (belonging either to B, A1, or CRF35_AD clades) did not group with the sequences obtained from Afghanistan and Iran. However, CRF35_AD clades from Afghanistan made two significant clusters with those strains from Iran. The results also showed that CRF35_AD clades from Afghanistan had more diversity than those in Iran suggesting its older presence in this country. Putting these findings together and considering drug trafficking/immigration events from Afghanistan to Iran we hypothesized that HIV epidemics might have been transmitted from Iran to Afghanistan. However, the reverse order might also be true but with less support from the existing evidence. There was no indication of Iran-Pakistan HIV transmission. Performing sophisticated evolutionary analysis is needed to test these hypotheses about the origin and transmission pattern of the virus among these countries.
کلیدواژه‌های انگلیسی مقاله Molecular Epidemiology, HIV-I, Afghanistan, Iran, Pakistan
نویسندگان مقاله فاطمه جهانبخش | fatemeh jahanbakhsh
pasteur institute of iran ipi ,no. 69, 12th farwardin ave, tehran, iran. post code 1316943551

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

ثنا عیب پوش | sana eybpoosh
pasteur institute of iran ipi ,no. 69, 12th farwardin ave, tehran, iran. post code 1316943551

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

احسان مصطفوی | ehsan mostafavi
pasteur institute of iran ipi ,no. 69, 12th farwardin ave, tehran, iran. post code 1316943551

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

علی اکبر حقدوست | aliakbar haghdoost
kerman university of medical sciences,medical university campus,haft-bagh highway, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

کیهان آزادمنش | kayhan azadmanesh
pasteur institute of iran ipi ,no. 69, 12th farwardin ave, tehran, iran. post code 1316943551

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-121-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/350/article-350-332410.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Epidemiologic studies including microbial genotyping, phenotyping and serotyping
نوع مقاله منتشر شده Short communication
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