این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Nanomedicine Journal، جلد ۱۲، شماره ۱، صفحات ۳۳-۴۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Microfluidic synthesis of pH-sensitive nanoparticles containing curcumin against breast cancer cell
چکیده انگلیسی مقاله Objective(s): Scientists have focused on the development of new drug delivery systems including pH-sensitive nanomaterials adaptive to tumor microenvironments. We aimed to fabricate a microfluidic system to synthesize and characterize curcumin (Cur)-containing PCL and Chitosan (CSN) polymeric nanoparticles against MCF7 breast cancer cells.Materials and Methods: The microfluidic chip was fabricated by photolithography and polydimethylsiloxane (PDMS) molding procedure. The chip was Y-shaped and equipped with two inlets and one outlet. PCL and Chitosan (CSN) were dissolved in acetic acid overnight and mixed with Cur for three hours. The prepared solution was injected from one inlet and a solution of tween 80 in distilled water was injected from the other inlet. The nanoparticles were characterized in size, electrical charge, structure, drug loading, and drug release efficiency. Finally, the cytotoxicity was assessed using the MTT assay at specific concentrations after 24 and 48 hr. Results: The mean diameter/zeta potentials of spherical-shaped nanoparticles with and without Cur were 209 ±2 nm / +15 and 219 ± 4 nm /+3 , respectively. FTIR results confirmed the presence of all components in the nanoparticles. The Cur loading rate was 1.5%, and Cur represented a sustained release manner. Also, the release profile showed faster release in a low-pH medium. MTT assay results showed that Cur-containing nanoparticles exerted a significant effect on cell viability. Conclusion: It can be concluded that microfluidic systems can pave the way for nanoparticle synthesis easily rapidly and cost-effectively for cancer agent delivery. Based on our observations, PCL-CSN-loaded Cur nanoparticles represent appropriate characteristics and suitable anti-cancer effects. 
کلیدواژه‌های انگلیسی مقاله Cancer cells, Chitosan microfluidics, Nanoparticles, PCL
نویسندگان مقاله | Nafiseh Nasirzadeh
Student Research Committee, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran|Department of Medical Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


| Ramin Hajian
Iranian Research Organization for Science and Technology (IROST), Tehran, Iran


| Samad Nadri
Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran|Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_25035.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده مقاله پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات