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Nanomedicine Journal، جلد ۱۲، شماره ۱، صفحات ۱۲۲-۱۳۹
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عنوان انگلیسی Synthesis of nano-liposomes containing Mentha piperita essential oil and investigating their stability, antimicrobial, antioxidant, and antiproliferative properties
چکیده انگلیسی مقاله Objective(s): Considering the problems of using medicinal plants in the treatment of diseases and the role of nanotechnology in reducing these challenges, the present research was conducted with the aim of preparing nano-liposomes containing Mentha piperita essential oil and investigating their physicochemical characteristics. Materials and Methods: Four nano-liposome formulations containing essential oil were prepared using cholesterol and phosphatidylcholine by thin layer method. Encapsulation efficiency, size, zeta potential, and essential oil release were measured in all formulations. The appropriate formulation was selected to investigate the morphology of the particles, their interaction between nano-liposomes and essential oil, toxicity, and antioxidant, antibacterial, and antifungal properties. Then, the stability of the selected formulation was checked for 120 days. Results: Formulation F1 was selected with an encapsulation efficiency of 62.12%, nano-particle size of 121 nm, and zeta potential of -21.8 mV. In this formulation, no interaction between nano-liposomes and essential oil was observed, and the spherical shape and two-layer nature of the nanoparticles were confirmed. Nano-liposomes with and without essential oil caused little toxicity to normal HFF cells and in all concentrations compared to free essential oil, they had more toxicity on MCF-7 cancer cells and higher antioxidant properties. The anti-proliferative effects of nano-liposomes on some microorganisms were higher than the free essential oil. Also,  there were slight changes in some physicochemical properties of nanoparticles during 120 days. Conclusion: Considering the suitable physicochemical properties of nano-liposomes containing essential oil and their anti-proliferative effects, these nano-systems can be suggested for further research in the field of cancer and microbial diseases.
کلیدواژه‌های انگلیسی مقاله Antioxidant, Antibacterial, Breast Cancer, Essential oil.Mentha piperita, Nano-liposomes
نویسندگان مقاله | Mohammad Majdizadeh
Nano-Biotech Foresight Company Biotechnology Campus, Science & Technology Park of Yazd, Yazd, Iran


| Sanaz Akbarzadeh
Department of Chemistry, Yasouj University, Yasouj, Iran|Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada


| Hussein H Al-Turnachy
Department of Biology, Faculty of Science, University of Kufa, Iraq


| Mahdie Hemati
5Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran|Biotechnology Research Center, International Campus, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Milad Akhlaghi
Biotechnology Research Center, International Campus, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Bibi Fatemeh Haghiralsadat
Biotechnology Research Center, International Campus, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran|Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Fatemeh Oroojalian
Natural Products and Medicinal Plants Research Center North Khorasan University of Medical Sciences Bojnūrd, Iran|Department of Medical Nanotechnology, School of Medicine, North Khorasan University of Medical Sciences, Bojnūrd, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_25106.html
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