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Middle East Journal of Digestive Diseases، جلد ۱۶، شماره ۴، صفحات ۲۳۰-۲۳۴
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عنوان انگلیسی Correlation between Autoimmune Hashimoto’s Thyroiditis and Helicobacter Pylori Infection: a Case-Control Study
چکیده انگلیسی مقاله Background: Among environmental factors, infectious agents, including Helicobacter pylori (H. pylori), can act as triggers for autoimmune thyroid diseases. Therefore, this study aimed to investigate the correlation between autoimmune Hashimoto’s thyroiditis with H. pylori infection. Methods: The participants in this case-control study were 74 individuals 17-62 years who were divided into two groups, including 38 diagnosed Hashimoto’s thyroiditis patients from an outpatient clinic of endocrinology and 36 apparently healthy individuals that were selected from family members of cases group age-matched and sex-matched. For individuals in two groups, a questionnaire was completed, including demographic information. Then, they were referred to the laboratory for thyroid stimulating hormone (TSH) and free T4 (FT4) in the control group and anti-thyroid peroxidase antibody (TPO-Ab) levels measurement in case and control groups. Stool samples were obtained from all individuals for H. pylori antigen detection using the ELIZA kit. Results: There was no significant difference in the mean age of case and control groups (P=0.96), and 81.1% of individuals were female. 58.6% of patients with Hashimoto’s thyroiditis and 41.4% of the control group had positive H. pylori, but there was no statistically significant difference between the two groups (P=0.34). Furthermore, there was a significant positive correlation between TPO-Ab levels and H. pylori infection (r =0.2, P=0.03). Conclusion:   TPO-Ab levels were associated with H. pylori infection diagnosed by H. pylori antigen.
کلیدواژه‌های انگلیسی مقاله Helicobacter pylori,Hashimoto’s thyroiditis,thyroid peroxidase antibody,thyroid stimulating hormone
نویسندگان مقاله | Mahla Shajari
Associate Professor of Endocrinology & Metabolism Department of Internal Medicine, School of Medicine, Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Maryam Rezaei
Assistant Professor of Biostatistics Department of Epidemiology and Biostatistics, School of Health, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Fereshteh Osmani
Assistant Professor of Medical Bacteriology, School of Medicine, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Ebrahim Shafaie
Professor of Physiology, Medical Toxicology and Drug Abuse Research Center, Department of Physiology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran


| Zoya Tahergorabi


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/3053
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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