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Middle East Journal of Digestive Diseases، جلد ۱۶، شماره ۴، صفحات ۲۳۵-۲۴۱
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عنوان انگلیسی Altered Cytokine Production in Patients with Helicobacter Pylori Infection
چکیده انگلیسی مقاله Background: Helicobacter pylori ( H. pylori ) is a gram-negative pathogen. The infection caused by this pathogen may result in gastritis and can increase the risk of gastric cancer. This study investigated the relationship between H. pylori infection as the main risk factor for gastritis and changes in serum inflammatory cytokine levels. Methods:  Blood samples from 85 patients with stomach pain, including 46 H. pylori -positive (Hp + ) and 39 H. pylori -negative (Hp - )cases, were collected and referred to a gastroenterologist. After isolation and identification of H. pylori , the severity of gastritis was determined for each patient based on the histopathological findings. Finally, the serum levels of cytokines were measured using the multiplex kit and flow cytometry methods. Results: There were significant differences in the levels of interleukin-2 (IL-2), IL-4, IL-17A, IL-17F, IL-22, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) between the Hp - and the Hp + specimens (P≤0.05). The levels of IL-2, IL-17A, IL-17F, IL-22, TNF-α, and IFN-γ were significantly higher in patients with mild and moderate gastritis than Hp - group (P≤0.05). In addition, IL-4 significantly increased in patients with moderate gastritis compared with Hp - individuals (P=0.008). Conclusion: Among the inflammatory cytokines evaluated in this study, IL-17A, IL-17F, and IL-22 may play a crucial role in developing moderate gastritis in infected patients with H. pylori .
کلیدواژه‌های انگلیسی مقاله Cytokines,Inflammation,Gastritis,Helicobacter pylori
نویسندگان مقاله | Abdollah Safikhani Mahmoodzadeh
Department of Microbiology, College of Sciences, Agriculture and Modern Technologies, Shiraz Branch, Islamic Azad University, Shiraz, Iran


| Elham Moazamian
Gastroenteropatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Seyedeh Azra Shamsdin
Department of Laboratory Sciences,School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Gholam Abbas Kaydani


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/3079
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