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Asia Pacific Journal of Medical Toxicology، جلد ۱۳، شماره ۳، صفحات ۸۴-۸۹
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عنوان انگلیسی Japanese Sake Yeast Potentially Attenuates Arsenic Neurotoxicity in Male Rats Model: Behavioral, Oxidative Stress, and Immunogenetics Assessment
چکیده انگلیسی مقاله Background: Arsenic (AS) is widely distributed in our surroundings, causing various health problems like neurological disorders. The current research was designed to investigate the effect of the anti-oxidant and anti-inflammatory content of sake yeast on the recovery of brain damage in an AS-treated rat's model with behavioral, oxidative stress, and immunogenetics assessment.Method: Twenty-four male rats were treated with AS (3 mg/kg b.wt. per day) alone or in combination form with sake (45 mg/kg b.wt. per day), and animals received them for 30 days in drinking water (n=6/group). The initial mechanism of action was explored by behavioral tests (rotarod, amphetamine rotation, and spatial memory(, oxidative assay, and histopathology methods.Results: Considering the vehicle group, induction of brain abnormalities by AS significantly (P<0.05) decreased the number of substantia nigra neurons, total antioxidant capacity, glutathione peroxidase activity and increased the amount of α-synuclein protein and led to the massive accumulation of malondialdehyde. Meanwhile, sake supplementation can rescue the brain damage caused by this toxic metal, resulting in a reduction of malondialdehyde and α-synuclein protein levels, plus a considerable improvement in blood serum total antioxidant capacity consideration (P<0.05). Activity behavioral tests confirmed the AS-mentioned changes by increasing the number of rotations and rod test time. Histopathology assays mimic the above data.Conclusion: In sum, the sake yeast supplement due to its properties positively influences for improvement of dopaminergic neuron dysfunction via AS damage.
کلیدواژه‌های انگلیسی مقاله α-synuclein, Arsenic, Brain, Oxidative stress, Sake
نویسندگان مقاله | Sadaf Saeedi
Department of Pathobiology, Faculty of veterinary sciences, science and Research branch, Islamic Azad university, Tehran, Iran


| Ali Olfati
Clinical Research Development Center, Motazedi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Tayebeh Sadeghi
Department of Physiology, Faculty of Medicine, Kerman Branch, Islamic Azad University, Kerman, Iran


| Firoozeh Veisi
Department Obstetrics & Gynecology, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Maryam Zanganeh
Department Obstetrics & Gynecology, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Nasrin Jalilian
Department Obstetrics & Gynecology, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Sareh Farshadfar
Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Samad Nazemi
Cellular and Molecular Research Center, Department of Physiology and Pharmacology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran


| Hamed Khorami
Department of Medical Chemistry, Ghadr University of Kuchesfahan, Gilan, Iran
نشانی اینترنتی https://apjmt.mums.ac.ir/article_25185.html
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