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Asia Pacific Journal of Medical Toxicology، جلد ۱۳، شماره ۳، صفحات ۹۵-۱۰۳
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عنوان انگلیسی Gender-dependent Side Effects of Two Highly Active Antiretroviral Therapy Regimens on HIV/AIDS Patients Attending Nsukka District Hospital, Nsukka, Enugu State, Nigeria
چکیده انگلیسی مقاله Background: This study evaluated the gender-dependent potency and side effects of Highly Active Antiretroviral Therapy regimens (i) Zidovndine/Lamuvidine/ Nevirapine (ii) Tenofovir/Emtricitabine/Effavirenz on HIV-positive/AIDs patients attending Nsukka district hospital Enugu, from January 2013 to December 2013. Method: A retrospective study of two hundred (200) patients of both sexes within the age bracket of 15 – 70 years attending Nsukka District hospital who were treated with HAART was conducted. Clinical and laboratory data were obtained through self developed validated data collection form.Results: Abdominal pains and diarrhea (3.3%) were the most reported clinical manifestations in regimen 1, followed by headache and chills (2.2%) while in regimen 2, headache, hotness and dizziness (2.4%) were the most reported clinical manifestations followed by pruritis. HAART 1 showed more adverse effects than HAART 2 on both sexes on most of the biochemical variables; glucose (34.57±95.97 - 4.89±0.3 mmol/l), cholesterol (17.33±39.87 - 3.63±0.62 mmol/l), serum glucotransaminase (SGOT) (36.78±27.76 - 32.83±17.10 iu/l), blood urea nitrogen (BUN), (18.66±13.33 - 15.14±6.01mg/dl) and amylase (126.29±186.21 - 104.43±31.38 µg/l).While  both regimens showed improved immunological and hematological outcomes: CD4+; 282.03±219.57 - 380.89±241.21 cells/µl (HAART1), 312.09±242.60-404.15±253.17 cells/µl (HAART2), hemoglobin(Hb) 10.60±1.74 - 10.93±1.81 g/dl (HAART1), 10.46 ±2.00 - 11.46±1.85 g/dl (HAART2).Conclusion: The adverse effects on clinical manifestation were more noticeable in regimen 1 in the study population, with the female population being the greater affected. Comparison of the two regimens with respect to their adverse effects on clinical manifestation favors regimen 2.
کلیدواژه‌های انگلیسی مقاله Gender-dependent, HIV/AIDS, HAART, Hematology, biochemical
نویسندگان مقاله | Okechukwu Asadu
Department of Pharmacology and Therapeutics, University of Nigeria, Enugu Campus, Enugu Nigeria|Nsukka District Hospital, Nsukka, Enugu State, Nigeria


| Chibuisi Otuu
Department of Science Laboratory Technology, University of Nigeria, Nsukka, Enugu State, Nigeria


| Nkoyo Nubila
Department of Pharmacology and Therapeutics, University of Nigeria, Enugu Campus, Enugu Nigeria


| Elvis Shu
Department of Pharmacology and Therapeutics, University of Nigeria, Enugu Campus, Enugu Nigeria
نشانی اینترنتی https://apjmt.mums.ac.ir/article_25187.html
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