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Journal of Midwifery and Reproductive Health، جلد ۱۳، شماره ۱، صفحات ۴۶۳۳-۴۶۴۱
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عنوان انگلیسی The Effect of Intravenous Ketamine on Analgesic Requirement after Spinal Anesthesia in Caesarean Section: a Randomized Clinical Trial
چکیده انگلیسی مقاله Background & aim: The use of opioids for pain relief after cesarean section (C/S) can result in adverse maternal and neonatal outcomes. Therefore, it is important to consider non-opioid analgesics as an alternative. This study examined the effect of intravenous ketamine on analgesic requirement after spinal anesthesia in C/S.Methods: This double-blind randomized clinical trial 80 pregnant women under spinal anesthesia during a planned C/S were recruited from trainig hospitals of Mashhad, Iran between February and August 2022. The participants were selected using convenience sampling and assigned to two intervention (40) and control (40) groups through random allocation. The intervention group received intravenous ketamine (0.5 mg/kg) and midazolam (0.02 mg/kg) immediately after umbilical cord clamping, while the control group received midazolam alone (0.02 mg/kg). Pain scores were recorded at the 0th, 6th, 12th, and 24th hours after elective C/S using the Visual Analog Score (VAS), along with the amount of requiremen to analgesics. Data analysis was performed by SPSS software (version 16) using Chi-square, T-test and repeated measure ANOVA test.Results: A significant difference in pain scores between the two groups at different hours and over time (P=0.009). The intervention group reported significantly lower levels of pain than the control group (P=0.002) and a significantly lower need for painkillers during the first hour (P=0.04).Conclusion: Administration of intravenous ketamine in elective C/S with spinal anesthesia in the first hour has a significant effect on reducing pain. Therefore, it can be considered the drug of choice for alleviating pain.  
کلیدواژه‌های انگلیسی مقاله Ketamine, Midazolam, Pain, Cesarean section, Spinal anesthesia
نویسندگان مقاله | Mitra Samedi
Anesthesiologist, Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Masoomeh Tabari
Associate Professor, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Elham Bakhtiari
Assistant Professor, Clinical Research Development Unit, Mashhad University of Medical Sciences, Mashhad, Iran


| Samaneh Abolbashari
PhD in Molecular Medicine, Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Saleheh Asghari
Anesthesiologist, Department of Anesthesiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://jmrh.mums.ac.ir/article_23360.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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