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Iranian Journal of Microbiology، جلد ۱۶، شماره ۶، صفحات ۷۸۰-۷۸۵
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عنوان انگلیسی Efficacy of traditional herb aqua extract of Teucrium stocksianum and its fractions against HSV-1 virus expression levels of genes (UL46 and US6)
چکیده انگلیسی مقاله Background and Objectives: Recently, the anti-herpetic activities of different plant species have been investigated. This study evaluated the effects of Teucrium stocksianum aqueous extract on the HSV-1 virus-infected Vero cell. Materials and Methods: The IC50 of the aqueous extract was obtained by the maceration of the plant in boiling water and has been measured with the MTT method, also the q-PCR was used to study viral gene expression reduction. Results: Results of the MTT test indicated that the highest percentage of metabolic activity was observed in the 75 μg/ml concentration of Teucrium stocksianum’s aqueous extracts (IC50=45.5μg/ml). Time intervals of 24 and 48 hours after viral infection revealed that the cell viability is reduced by the viral infection time (MOI=0.1), log 10-3, p <0.001). Furthermore, the plant’s aqueous extract concentration almost avoids cell viability reduction. Through Q-PCR results; the reduction of viral proliferation revealed that the low expression of genes UL46 and US6 were significant in the presence of different treatments utilized in the experiment. Conclusion: T. stocksianum, has an anti-viral property and may be considered as a remedy for anti-HSV-1 agents.
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نویسندگان مقاله | Emad Asgari
Department of Theriogenology, School of Veterinary Medicine, University of Tehran, Tehran, Iran


| Zohreh Sharifi
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran


| Farahnaz Bineshian
Department of Parasitology and Mycology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran


| Mahsa Zamanian
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4723
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