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Iranian Journal of Microbiology، جلد ۱۶، شماره ۶، صفحات ۷۹۲-۸۰۲
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عنوان انگلیسی Distribution of fungal agents in the respiratory system of patients with underlying lung diseases; molecular identification and antifungal susceptibility profiles
چکیده انگلیسی مقاله Background and Objectives: Airway fungal infection is a severe clinical problem, especially in patients with compromised immune functions. Here, we examined the distribution and antifungal susceptibility profiles of fungal agents isolated from respiratory tract of symptomatic patients hospitalized in pulmonary units. Materials and Methods: This descriptive cross-sectional study took place from 2023 to 2024, involving 360 patients. Bronchoalveolar lavage (BAL) or sputum specimens were collected and analyzed using mycological and molecular methods for this study. Antifungal susceptibility testing (AFST) was carried out using the broth micro dilution method. Results: Of a total of 360 respiratory specimens, 114 (31.6%) were positive. The male-to-female ratio was 63:51 (1.3%). Candida albicans and Aspergillus flavus were the most common yeast and mold species. Chronic obstructive pulmonary disease (COPD) had the highest rate of colonization with fungal agents (47/114, 41%). The isolates associated with COPD in this study included Aspergillus species (4/12, 3.5%), Candida species (41/96, 36%), and other fungal species (2/6, 1.5%). Coughing (87%) was the predominant symptom, and malignancy (52%) was the predominant comorbidity factor. The result of AFST for antifungal agents showed that 9 (22.5%) Candida isolates were resistant, and the highest rate of resistance was related to voriconazole agent (5/9, 55.5%). Resistance to antifungal agents was not observed among Aspergillus isolates. Conclusion: This study showed a significant relationship between the frequency of Aspergillus and Candida species in patients with underlying lung diseases. In addition, voriconazole was more effective than itraconazole, especially against Aspergillus flavus.
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نویسندگان مقاله | Parviz Hassanpour
Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Seyed Jamal Hashemi
Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Sanam Nami
Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Roshanak Daie Ghazvini
Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Behrouz Naghili Hokmabadi
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Abbas Rahimi Foroushani
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Kazem Ahmadikia
Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Zahra Ramezanalipour
Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Saeid Firouzi Abriz
Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4825
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