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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۲، صفحات ۲۳۰-۲۳۶
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Curcumin exerts protective effects against valproic acid-induced testicular damage through modulating the JAK1/STAT–3/IL–6 signaling pathway in rats
چکیده انگلیسی مقاله Objective(s): This experiment was carried out to investigate the protective effects of curcumin (CUR) on testicular damage induced by the valproic acid (VPA) administration. Materials and Methods: Male Wistar–Albino rats (n=28, 250–300 g) were randomly divided into four groups: Control (1 ml saline, oral), VPA (500 mg/kg, IP), CUR (200 mg/kg, oral), or VPA+CUR (500 mg/kg, VPA, IP plus 200 mg/kg CUR, oral). The treatments were applied for 14 days. Serum testosterone and testis [Janus kinases1 (JAK1), signal transducers and activators of transcription–3 (STAT–3), interleukin–6 (IL–6), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF–α), interleukin–18 (IL–18), and nuclear factor (NF)–κB)] samples were collected for biochemical analyses. Semen samples were subjected to microscopy for spermatological parameters. Testis tissue was also analyzed for histopathological and immunohistochemical methods. Results: The VPA administration caused a 37% decrease in serum testosterone concentration and 5.32, 9.51, 2.44, and 3.68–fold increases in testicular tissue JAK1, STAT–3, IL–6, and MDA levels, respectively. There were also 50, 52, and 72% reductions in sperm motility, sperm viability, and the mean testicular biopsy score, respectively, accompanied by considerable degenerative changes and necrosis in seminiferous tubules in the VPA group. There is also an immune-positive reaction for IL–18 and NF–κB in only Leydig cells. Conclusion: The CUR treatment may be beneficial in restoring testicular damage through antiinflammatory and anti-oxidant potential.
کلیدواژه‌های انگلیسی مقاله Curcumin, Interleukin–6, Janus kinases, Testicular damage, Valproic acid
نویسندگان مقاله | Eda Dokumacioglu
Eda Dokumacioglu, Department of Nutrition and Dietetics, Faculty of Health Sciences, Artvin Coruh University, Artvin 08000, Turkey


| Hatice Iskender
Eda Dokumacioglu, Department of Nutrition and Dietetics, Faculty of Health Sciences, Artvin Coruh University, Artvin 08000, Turkey


| ismail Bolat
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, Turkey


| Kubra Kapakin
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, Turkey


| Behzat Mokhtare
Department of Pathology, Faculty of Veterinary Medicine, Dicle University, Diyarbakır, 21000, Turkey


| Ali Omur
Ali Dogan Omur, Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, Turkey


| Armagan Hayirli
Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, Turkey
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25147.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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