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Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۱، صفحات ۸۴۸-۸۵۹
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عنوان انگلیسی The therapeutic potential of Ma'aljobon, a whey product, in primary hypertension: A double-blind randomized controlled trial
چکیده انگلیسی مقاله Objective: Ma’aljobon is used in Persian medicine (PM) as a natural antihypertensive product. This study aimed to evaluate the hypotensive effect of Ma’aljobon in patients with uncontrolled grade 1 primary hypertension (HTN).Materials and Methods: This double-blind, placebo-controlled clinical trial included 114 patients (20-80 years) with uncontrolled grade 1 primary HTN. After obtaining informed consent, the participants were randomly divided into two groups and administered with 25g of Ma’aljobon or maltodextrin twice daily for six weeks. Systolic and diastolic blood pressures (SBP and DBP, respectively) were analyzed.Results: A total of 97 patients (52.3±10.7 years, %53.6 female) completed the study. In the Ma’aljobon group, SBP decreased from 150.3±12.3 to 130.6±12.1 mm Hg, and DBP decreased from 93.3±8.2 to 80.1±6.6 mm Hg (p<0.001). In the control group, SBP decreased from 147.6±11.2 to 138.7±14.4 mm Hg, and DBP decreased from 86.6±7.7 to 82.2±8.2 mm Hg (p<0.001). There was a significant difference in the changes of SBP and DBP between the two groups over time (p<0.001). No adverse events were observed.Conclusion: Ma’aljobon has a stronger hypotensive effect than placebo in patients with HTN and can be recommended as an add-on therapy for uncontrolled HTN.
کلیدواژه‌های انگلیسی مقاله Hypertension, Persian Medicine, Whey Proteins, Traditional Medicine
نویسندگان مقاله | Asie Shojaii
Department of Traditional Pharmacy, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran


| Roshanak Ghods
Department of Traditional Medicine, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran


| Fataneh Hashem-Dabaghian
Department of Traditional Medicine, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran


| Maryam Navabzadeh
Department of Persian Medicine, Birjand University of Medical Sciences, Birjand, Iran


| Tooba Kazemi
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Morné Weyers
African Medicines Innovations and Technologies Development (AMITD), Indigenous knowledge based Medicines and Innovations Centre, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South Africa


| Motlalepula G. Matsabisa
Department of Pharmacology, African Medicines Innovations and Technologies Development (AMITD), Indigenous knowledge based Medicines and Innovations Centre, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South Africa
نشانی اینترنتی https://ajp.mums.ac.ir/article_24921.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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