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Veterinary Research Forum، جلد ۱۵، شماره ۱۲، صفحات ۶۶۵-۶۷۲
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عنوان انگلیسی Protective effects of Mito-TEMPO on ischemia-reperfusion injury in a mouse testicular torsion and detorsion model
چکیده انگلیسی مقاله Testicular ischemia-reperfusion (I/R) injury during testicular torsion is strongly influenced by oxidative stress caused by excessive accumulation of unscavenged reactive oxygen species. This study aimed to investigate the effects of intra-peritoneal administration of Mito-TEMPO (MT) on I/R injury in testicular torsion/detorsion (T/D) in mice. Forty-two male mice were divided into seven groups including 1 control and 6 treatment groups (360° T/D, 720° T/D, 360° T/D + 0.70 mg kg-1 MT, 360° T/D + 1.00 mg kg-1 MT, 720° T/D + 0.70 mg kg-1 MT, and 720° T/D + 1.00 mg kg-1 MT). After inducing 360° and 720° clockwise testicular torsions for 2 hr, sperm parameters, apoptosis-related genes expression, and in vivo fertility index were evaluated. The results showed that 720° T/D can lead to increased abnormal sperm morphology, sperm DNA damage, and Bax expression, while the Bcl-2 expression was reduced compared to the other groups. In addition, it also had negative effects on sperm total and progressive motilities as well as viability and plasma membrane functionality (PMF). The results also showed that administration of MT to T/D mice can result in a reduction in abnormal sperm morphology, DNA damage, and Bax expression. It could also increase sperm total and progressive motilities, viability and PMF, Bcl-2 expression, and in vivo fertility index. Based on our results, it is concluded that MT, when administered after spermatic cord torsion in mice, provides significant protection against acute testicular T/D injury.
کلیدواژه‌های انگلیسی مقاله Mice,Reperfusion Injury,Spermatic cord torsion,Testis
نویسندگان مقاله Zohreh Mostahsan |
DVSc Candidate, Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Saeed Azizi |
Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Ali Soleimanzadeh |
Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Ali Shalizar |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

نشانی اینترنتی https://vrf.iranjournals.ir/article_718216_4e5d27965b635dc40851e1854794d714.pdf
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