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Research Journal of Pharmacognosy، جلد ۱۲، شماره ۱، صفحات ۱-۱۰
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عنوان انگلیسی Hypnotic Activity of Carthamus tinctorius Petal Extracts and Its Purified Components
چکیده انگلیسی مقاله Background and objectives: Sleep disorders are common in industrialized and developing societies. This study aimed to investigate the sleep-inducing potential of Carthamus tinctorius L. (safflower) fractions and purified components on insomnia based on Iranian traditional medicine references. Methods: The methanol extract of safflower petals and the hexane, ethyl acetate, and methanol fractions were prepared. Additionally, a Carthamus red pigment fraction was obtained through alkaline extraction (with sodium carbonate) and acidic precipitation (with citric acid). The red pigment fraction was further isolated using semi-preparative high-performance liquid chromatography. The hypnotic activity of these fractions and purified compounds was assessed using the pentobarbital-induced loss of righting reflex test. Results: Both the ethyl acetate and red pigment fractions at 200 mg/kg demonstrated significant hypnotic activity compared to the control group. In contrast, hexane and methanol fractions showed no significant effects at 200 mg/kg. The hypnotic effect of the red pigment fraction was dose-dependent (100, 150, 200 mg/kg). Purification resulted in three major compounds: EEE (1), EZE (2), and EZZ (3), isomers of N1, N5, N10-tri-p-coumaroylspermidine, which exhibited significant hypnotic activity at 15 mg/kg, antagonized by flumazenil (2 mg/kg). Conclusion: Our findings suggest that safflower extract exhibits a dose-dependent hypnotic effect, with tri-p-coumaroylspermidine identified as the primary active compound. This activity is at least partly linked to gamma-aminobutyric acid (GABA) receptors. However, further investigation is needed to elucidate the underlying mechanism and potential side effects.
کلیدواژه‌های انگلیسی مقاله coumaroylspermidine,hypnotic,LC-MS,NMR,Safflower
نویسندگان مقاله Abdorahim Nouri |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mahdi Vazirian |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Hamid Reza Monsef Esfahani |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Sharifzadeh |
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Reza Jahani |
Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mehran Mirabzadeh Ardakani |
Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Mahnaz Khanavi |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Reza Shams Ardekani |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی https://www.rjpharmacognosy.ir/article_209877_07b55b8f63330899c8db8e834aa7a5d5.pdf
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