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Iranian Heart Journal، جلد ۲۶، شماره ۱، صفحات ۳۵-۵۳
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عنوان انگلیسی Efficacy and Safety of Lasunairandadi Kashayam, an Ayurvedic Formulation, as Adjunctive Therapy in Patients with Coronary Artery Disease: A Randomized Clinical Trial
چکیده انگلیسی مقاله Background: Coronary Artery Disease (CAD) is the leading global cause of mortality, with its prevalence rising alarmingly in developing countries. While conventional treatments have limitations, traditional medicines like the Ayurvedic formulation Lasunairandadi Kashayam (decoction), historically used for cardiovascular conditions, necessitate rigorous scientific validation to confirm their efficacy and safety. The present study aimed to evaluate the use of that formulation as an adjunct therapy for CAD patients.   Methods: This randomized clinical trial involved 53 patients diagnosed with CAD, aged 25 to 60 years. Participants were randomly assigned to an intervention group (Lasunairandadi Kashayam plus the standard CAD treatment, n = 26) or a control group (the standard CAD treatment alone, n = 27). The intervention group received a daily dose of Lasunairandadi Kashayam for 90 days (32 mL thrice a day before meals). Primary endpoints assessed included improvements in treadmill test (TMT) scores, dyspnea on exertion, chest heaviness, chest pain, overall cardiovascular health, and lipid profiles.   Results: The intervention group showed statistically significant ameliorations in key CAD parameters compared with the standard therapy group. Notable enhancements were observed in TMT scores (from −7.0 ± 5.5 before treatment to +4.41 ± 5.2 after treatment), dyspnea on exertion, chest heaviness, chest pain, and overall cardiovascular health. Significant reductions were recorded in low-density lipoprotein-cholesterol (from 102.63 ± 29.94 before treatment to 89.50 ± 17.56 after treatment) and triglycerides (from 169.09 ± 63.79 before treatment to 145.59 ± 29.34 after treatment) in the intervention group. The safety profile was favorable, with no serious adverse effects reported.   Conclusions: Lasunairandadi Kashayam, as an adjunctive therapy to standard CAD treatment, recorded promising results in improving clinical outcomes for CAD patients. This study contributes valuable evidence toward integrating Ayurvedic interventions into mainstream cardiovascular care. (Iranian Heart Journal 2025; 26(1): 35-53)
کلیدواژه‌های انگلیسی مقاله Ameliorations,Diseased vessels,Lasunairandadi Kashayam,Efficacy,safety
نویسندگان مقاله Kasthuri Nair A |
Department of Kayachikitsa, Pankajakasthuri Ayurveda Medical College and P.G. Center, Killy, Kattakada, Thiruvananthapuram, Kerala, India.

Arun Pratap |
Department of Kayachikitsa, Pankajakasthuri Ayurveda Medical College and P.G. Center, Killy, Kattakada, Thiruvananthapuram, Kerala, India.

Hareendran Nair J |
Department of Samhitha, Sanskrit and Siddhaanta, Pankajakasthuri Ayurveda Medical College and P.G. Center, Killy, Kattakada, Thiruvananthapuram, Kerala, India.

Jishnu R |
Department of R&D, Pankajakasthuri Herbal Research Foundation, Thiruvananthapuram, Kerala, India.

نشانی اینترنتی https://journal.iha.org.ir/article_212298_5d0d566b66f334d124bb7f9517bfa032.pdf
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