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Iranian Heart Journal، جلد ۲۶، شماره ۱، صفحات ۸۱-۹۲
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عنوان انگلیسی High-Intensity Interval Training and Crocin Effects on Doxorubicin-Induced Heart Apoptosis
چکیده انگلیسی مقاله Background: Doxorubicin (Dox) has been shown to negatively impact the function and structure of the heart in several studies. This experimental study examined the effects of 8 weeks of high-intensity interval training (HIIT) and crocin (Cr) on Dox-induced apoptosis in the heart tissue of male Wistar rats.   Methods: Fifty healthy male Wistar rats (8 weeks, 200–220 g) were utilized in this study. The groups under investigation included Dox (2 mg/kg), Dox + HIIT (5 days/week for 8 weeks), Dox + Cr (10 mg/kg), and Dox + Cr + HIIT. HIIT involved 1 hour of running at 40%–60% of maximum speed, 5 days per week. Apoptosis and histological changes were assessed in the heart tissue of the rats. Results: Dox significantly increased the expression of Bax while decreasing Bcl-2 expression levels in the cardiac tissue of animals (P < 0.01). The combination of HIIT and Cr reduced the heart injury score, TUNEL-positive cells, and the Bax/Bcl-2 ratio in Dox-treated rats compared with HIIT or Cr alone.   Conclusions: Cr and HIIT, either individually or combined, demonstrated potential in suppressing Dox-induced cardiotoxicity through the attenuation of apoptosis and histological injury. (Iranian Heart Journal 2025; 26(1): 81-92)
کلیدواژه‌های انگلیسی مقاله cardiotoxicity,High-intensity interval training,Crocin,Apoptosis
نویسندگان مقاله Rahmatullah Khanmohammadi |
Department of Exercise Physiology, Behbahan Branch, Islamic Azad University, Behbahan, IR Iran.

Mohamad Ali Azarbayjani |
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, IR Iran.

Maghsoud Peeri |
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, IR Iran.

Layasadat Khorsandi |
Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.

نشانی اینترنتی https://journal.iha.org.ir/article_212303_2cf5f9d1f8741a7c1c16e9260620f148.pdf
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