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Journal of Arthropod-Borne Diseases، جلد ۱۸، شماره ۲، صفحات ۱۷۲-۱۷۹
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عنوان انگلیسی Neutrophil Extracellular Traps Contribute to the Disease Severity of Dengue Virus Infection
چکیده انگلیسی مقاله Background: The spectrum of dengue infection ranges from asymptomatic or mild to severe disease. The pathogenic mechanisms are not fully understood. A viral infection can induce the neutrophil extracellular traps (NETs), and the excessive NETs lead to increased vascular permeability, coagulopathy, and platelet dysfunction, a hallmark of severe dengue. Methods: To evaluate the association of NETs formation with disease severity using a human public transcriptomic dataset (GSE17924) and clinical samples from dengue patients with different disease severity.  Results: Based on the transcriptomic analysis, the whole blood gene expression functional in neutrophil activities and NETs formation was upregulated with dengue disease severity. The serum concentration of citrullinated histone H3 (CitH3), a NETs marker, was measured in 28 dengue patients, of whom 18 classified as dengue fever (DF) and 10 as dengue hemorrhagic fever (DHF) grade 1 and 2. A significantly higher CitH3 concentration was found in DHF com­pared to DF patients. The level of CitH3 was negatively correlated with platelet counts. Conclusion: Our results suggest NETs have contributed to the disease severity of dengue infection. Future studies on the predictive value of NETs markers and the potential NETs as a targeted therapy in dengue disease should be priori­tized.
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نویسندگان مقاله | Cucunawangsih Cucunawangsih
Department of Microbiology, Faculty of Medicine, Pelita Harapan University, Tangerang, Indonesia


| Ratna Wijaya
Department of Microbiology, Faculty of Medicine, Pelita Harapan University, Tangerang, Indonesia


| Nata Lugito
Department of Internal Medicine, Faculty of Medicine, Pelita Harapan University, Tangerang, Indonesia


| Ivet Suriapranata
Division of Immunology, Mochtar Riady Institute for Nanotechnology and Medical Science Group, Pelita Harapan University, Tangerang, Indonesia
نشانی اینترنتی https://jad.tums.ac.ir/index.php/jad/article/view/1632
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