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Iranian Journal of Otorhinolaryngology، جلد ۳۷، شماره ۱، صفحات ۳۳-۳۹
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عنوان انگلیسی The Effect of Coenzyme Q10 on Tinnitus Severity and Sleep Quality in Patients with Presbycusis
چکیده انگلیسی مقاله Introduction: Tinnitus is one of the symptoms of presbycusis that affects patients' sleep and social life. This study aimed to determine the effect of coenzyme Q10 (CoQ10) on treating tinnitus due to presbycusis. Materials and Methods: In this double-blind, randomized clinical trial, 50 patients with tinnitus due to presbycusis were randomly divided into groups A and B, with 25 patients in each group. In addition to routine treatments, group A received 100 mg of CoQ10 daily, while group B received a placebo. Both groups were evaluated for tinnitus severity, loudness of tinnitus, quality of life, and sleep disturbance before and 6 weeks after starting the treatment. Results: In the intervention and control groups, the mean changes in score compared to before the treatment were as follows: quality of life (3.1 ± 1.67) and (1.28 ± 0.76) (P = 0.298), sleep disorder (-7.60 ± 1.38) and (-1.0 ± 8.55) (P<0.001), tinnitus disability (-17.2 ± 52.93) and (-4.56 ± 1.37) (P<0.001), tinnitus loudness of right ear (-1.68 ± 0.41) and (-0.95 ± 0.23) (P=0.11) and left ear (-2.2 ± 0.35) and (-0.54 ± 0.21) (P<0.001). Conclusion: This study indicated that adding CoQ10 to the routine regimen for patients with tinnitus due to presbycusis significantly decreases tinnitus disability, improves sleep disturbance, and reduces tinnitus loudness. However, more studies should be conducted in this regard.
کلیدواژه‌های انگلیسی مقاله Coenzyme Q10, Presbycusis, Tinnitus
نویسندگان مقاله | Rohollah Abbasi
Department of Otolaryngology Head and Neck Surgery, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.


| Faranak Emami
Department of Audiology, School of Rehabilitation, Hearing Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.


| Saeid Atighechi
Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Zahra Sadeghi
Department of Otolaryngology Head and Neck Surgery, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
نشانی اینترنتی https://ijorl.mums.ac.ir/article_25400.html
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