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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۳، صفحات ۳۴۷-۳۵۴
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عنوان انگلیسی Protective immune response induced by cationic liposomes bearing soluble antigens improves the survival of BALB/c mice against Toxoplasma gondii RH strain
چکیده انگلیسی مقاله Objective(s): An ideal strategy to control acute or chronic toxoplasmosis can be the development and production of an effective vaccine. Liposomes as immunoadjuvants may be utilized to boost immune reactions for various antigens.Materials and Methods:  In this study, we encapsulated soluble Toxoplasma antigen (SA) in 1, 2-Dioleoyl-3-trimethylammonium propane (DOTAP) liposomes to assess the elicited immunological response. BALB/C mice received three intramuscular injections of various formulations separated by two weeks. The kind of immune reaction that was created, the degree of protection, the percentage of BALB/c mice that survived the Toxoplasma gondii challenge, the immune reaction assessment with cytokine synthesis (IFN-γ, IL-4), and the titration of IgG isotypes were all evaluated.Results: Compared to other groups, the liposome DOTAP + imiquimod + SA-immunized mice showed a significantly lower death rate (P<0.01). Liposome DOTAP + Imiquimod + SA had higher IgG2a and IFN-γ secretion levels than the control group (P<0.001 and P<0.0001, respectively).Conclusion: According to the study’s findings, the liposome DOTAP + imiquimod + SA formulation generates a cellular immunological response, making it resistant to the T. gondii challenge.
کلیدواژه‌های انگلیسی مقاله Adjuvant, Cationic Liposome, Immune response, Survival rate, Toxoplasma gondii
نویسندگان مقاله | Hadi Mirahmadi
Department of Parasitology and Mycology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran|Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran


| Ahmad Mehravaran
Department of Parasitology and Mycology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;Infectious Diseases and Tropical Medicine Research Center, Research Institute of Cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran


| Mahdi Kavand
Department of Parasitology and Mycology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Ali Reza Salimi Khorashad
Department of Parasitology and Mycology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran|Infectious Diseases and Tropical Medicine Research Center, Research Institute of Cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran


| Nasreen Rezaei
Health and Treatment Network of Mehran City, Ilam University of Medical Sciences, Ilam, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25367.html
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نوع مقاله منتشر شده Original Article
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