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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۳، صفحات ۳۶۶-۳۷۵
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عنوان انگلیسی Comparing the effect of plasma therapy with estradiol valerate in motor and cognitive behavioral disorders in ovariectomized old rats: Behavioral, biochemical, and protein expression
چکیده انگلیسی مقاله Objective(s): This study investigated the effects of young plasma therapy (YPT) compared to estrogen therapy (E2T) on motor and cognitive impairments in aged ovariectomized (OVX) rats.Materials and Methods: Sixty female Wistar rats were divided as follows: 1). 2-3 months control young group. Five 22-24 months old groups: 1) Control, 2) Sham, 3) OVX, 4) OVX.E2, and 5) OVX.YP. Young plasma (1 ml plasma, through the tail vein, 3 days weekly for 4 weeks) and E2 (30 mg/kg, SC, 5 days weekly for 4 weeks) were administrated to OVX rats. The open field, elevated plus maze, and Barne’s maze were used to assess the behaviors. Then, miR-134 and miR-124 (RT- RCR), SIRT1, CREB, and BDNF (western blot), and anti-oxidants/oxidants markers (Photometry) levels were assessed in the rat’s hippocampal tissues.Results: OVX caused up-regulated hippocampal miR-134 and miR-124 expression levels (P<0.001) while down-regulated SIRT1, CREB, and BDNF protein expressions (P<0.001). Also, ovariectomy Increased TOS, OSI, and MDA (P<0.001) while decreasing TAC (P<0.001) compared to sham. Treatment with both E2T and YPT significantly improved all oxidative stress indexes (P<0.0.001) and increased p-CREB, BDNF, and SIRT1 protein levels (P<0.05, P<0.01) while decreasing the expression of miR-134 and miR-124 (P<0.001). Conclusion: YPT is a non-pharmacological therapeutic as much as or more than E-2T, which can exhibit anti-oxidative and anti-inflammatory potential in the hippocampal tissue and improve cognitive deficits in aged OVX rats without unknown side effects.
کلیدواژه‌های انگلیسی مقاله Cognition, Estradiol valerate, Motor, Ovariectomy, Protein expression, Young plasma
نویسندگان مقاله | Maryam Khajvand-Abedini
Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Mohammad Mohammadi
2 Department of Medical Laboratory Science, Faculty of Medicine, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran


| Parisa Habibi
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Zahra Shahabi‬
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Siamak Shahidi
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Naser Ahmadiasl
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Mohammad Reza Alipour
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Mahdi Ramezani
Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Alireza Komaki
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25360.html
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نوع مقاله منتشر شده Original Article
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