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Journal of Cardio-Thoracic Medicine، جلد ۱۲، شماره ۳، صفحات ۱۳۶۱-۱۳۷۳
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عنوان انگلیسی Lymph Node and Bone Marrow Micro-Metastasis in Patients with Esophageal Cancer
چکیده انگلیسی مقاله Esophageal cancer (EC) is the sixth most common cause of cancer-related mortality globally, due to the high frequency of early metastatic disease. In the past, the presence of metastasis was examined based on histological analysis using hematoxylin and eosin (HE) staining. A high percentage of patients experience recurrence after metastasectomy. Recurrence could be due to the presence of micro-metastasis (MM), which could be detected at sites such as lymph nodes or bone marrow using RT-PCR or immune-histochemical staining. Previous studies have reported inconsistent results with respect to the clinical significance of MM, its impact on survival, and how it is affected by chemotherapy. In this study, we reviewed the (1) clinical significance of MM, (2) methods of detection, (3) sites of occurrence, (4) the mechanism associated with MM, and (5) the role of chemotherapy and radiotherapy in patients with EC.
کلیدواژه‌های انگلیسی مقاله Esophageal Cancer, Esophageal squamous cell carcinoma, Esophageal adenocarcinoma, Micro-Metastasis, Lymph node, Bone marrow
نویسندگان مقاله | Ali Esparham
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Fatemeh Sadat Hashemi Javaheri
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.


| Sara Saffar Soflaei
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.


| Gordon A. Ferns
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.


| Majid Ghayour-Mobarhan
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.


| Maryam Saberi-Karimian
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.


| Reza Bagheri
Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
نشانی اینترنتی https://jctm.mums.ac.ir/article_24967.html
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نوع مقاله منتشر شده Review Article
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