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Journal of Biostatistics and Epidemiology، جلد ۱۰، شماره ۲، صفحات ۱۳۲-۱۴۹
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عنوان انگلیسی A Review of Mendelian Randomization in the Presence of Weak Instrumental Variables; Statistical Methods and Challenges
چکیده انگلیسی مقاله The genetic variant of interest is referred to be a weak instrumental variable in Mendelian randomization If the relevance assumption is not met. By and large, a weak instrument bias occurs when there is insufficient statistical evidence to support an association between IV and exposure. Weak instruments can result in a variety of problems, including (i) insufficient statistical power to hypothesis testing, (ii) increasing bias with deviation from IV assumptions, and (iii) asymptotic estimation of standard errors and confidence intervals. Several statistical techniques have been presented thus far for reducing weak instrumental bias. However, the absence of a comprehensive document comparing and reviewing all of these strategies is particularly evident. As such, we seek to present an overview of Mendelian Randomization, the challenges associated with weak instrumental bias, an adequate statistical remedy for weak instrumental bias, and the limits of MR, as well as a critical comparison.
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نویسندگان مقاله | Danial Habibi
isfahan university of medical sciences


| Maryam S Daneshpour
Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Marjan Mansourian
Department of Biostatistics and Epidemiology, Faculty of Health, Isfahan University of Medical Sciences, Isfahan, Iran


| Mahdi Akbarzadeh
Cellular, and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://jbe.tums.ac.ir/index.php/jbe/article/view/1442
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