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Iranian Journal of Pathology، جلد ۱۹، شماره ۴، صفحات ۴۱۵-۴۲۱
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عنوان انگلیسی Histopathological Evaluation of PYGO2 Expression in Esophageal Squamous Cell Carcinoma
چکیده انگلیسی مقاله Background & Objective: Esophageal squamous cell carcinoma (ESCC) is one of the world's deadliest cancer diseases. Deregulation of developmental signaling pathways such as Wnt/β-catenin is frequently implicated in a wide range of human cancers. The present study was designed to analyze the expression of the Pygopus2 (PYGO2) protein, the main co-activator of the Wnt/β-catenin signaling pathway, in ESCC tissues and evaluate its probable correlation with clinicopathological features of patients.
Methods: In this study, PYGO2 protein expression was assessed in tumors and margin normal tissues from 50 ESCC patients using immunohistochemical analysis, and its clinicopathological relevance in the patients was evaluated.  
Results: A significant PYGO2 overexpression was observed in %32 of the tumor cells. Interestingly, PYGO2 expression was significantly correlated with the depth of tumor invasion (P= 0.021).
Conclusion: PYGO2 protein may be highly expressed in ESCC in correlation with the invasiveness of the disease. Therefore, it may be used as a biomarker for the diagnosis of invasive ESCC and a putative therapeutic target to inhibit ESCC invasiveness.
کلیدواژه‌های انگلیسی مقاله Esophageal squamous cell carcinoma,Immunohistochemistry,PYGO2,Wnt/β-catenin signaling pathway
نویسندگان مقاله Sima Ardalan Khales |
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Habibeh Rahmani Kalat |
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

Sedigheh Soleymani |
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

Amir Hossein Jafarian |
Department of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Mahdi Forghanifard |
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_720125_bf73534ff1c52c50cb43d2a422820a97.pdf
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