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Basic and Clinical Neuroscience، جلد ۱۶، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی L-α-aminoadipic Acid-Induced Astrocytes Inhibition in the Hippocampal CA1 Region Leads to Anxiety-like Behavior and Memory Impairment
چکیده انگلیسی مقاله
Background: Glutamate plays a major role in synaptic plasticity that is important for learning and memory. Astrocyte is important neuroglia, involves in the neuroinflammation and plays a key role in maintaining glutamine/glutamate homeostasis. As astrocytes provide a vital support to neurons in pathological conditions. Hence, in this study, we aimed to evaluate the effect of hippocampal astrocytes ablation induced by microinjection of L-α-aminoadipic acid (L-α-AAA) on memory, anxiety and the density of GFAP-ir astrocytes in the hippocampus.
Methods: Adult male Wistar rats were randomly assigned to control, vehicle, and experimental group. L-α-AAA was injected into the hippocampal CA1 subfield for 3 days. Memory was evaluated by inhibitory passive avoidance test and anxiety-related behavior was assessed by elevated plus maze apparatus. Hippocampal sections were immunostained for GFAP and the density of GFAP-ir astrocytes were counted.
Results: Microinjection of L-α-AAA into the CA1 subfield of the hippocampus significantly decreased the step-through latency time in passive avoidance test and significantly decreased time spent in open arm and increased time spent in closed arm in elevated plus maze test. Also, administration of L-α-AAA significantly declined the density of GFAP-ir astrocytes in the hippocampus.
Conclusion: Inhibition of astrocytes impaired the memory and increased the anxiety-like behavior in male rats. Hence, the current study confirmed hippocampal astrocyte’s key role in memory and anxiety-like behavior which can be considered in future therapeutic strategies.
کلیدواژه‌های انگلیسی مقاله Astrocyte, GFAP, L-α-Aminoadipic acid, Anxiety, Memory, Hippocampus
نویسندگان مقاله | Mehrdad Jahanshahi
Neuroscience Research Center, Department of Anatomy, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.


| Leila Elyasi
Neuroscience Research Center, Department of Anatomy, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.


| Emsehgol Nikmahzar
Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-93-6&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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