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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۴، صفحات ۴۴۴-۴۵۰
عنوان فارسی
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عنوان انگلیسی Pre- and post-traumatic boric acid therapy prevents oxidative stress-mediated neuronal apoptosis in spinal cord injury
چکیده انگلیسی مقاله Objective(s): In our study, the neuroprotective efficacy of pre- and post-traumatic applications of boric acid (BA) in rats with experimentally induced spinal cord injury (SCI) was investigated.Materials and Methods: The experimental animals were divided into four groups: control group (C), SCI group (SCI), BA-treated group before SCI (BA+SCI), and BA-treated group after SCI (SCI+BA). Forty-eight hours after SCI, biochemical levels of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and cytochrome c (Cytc) and caspase-3 (Casp3) expressions were measured in the spinal cord tissues and were examined histologically.Results: After SCI, oxidative stress markers, such as MDA, TOS, and OSI, and apoptosis markers Cytc and Casp3 showed an increase in levels compared to Group C. The oxidative stress markers that increased after SCI decreased with BA+SCI application, while Cytc level, one of the apoptosis markers that increased after SCI, decreased in both groups with BA application. Cell, myelin, ependymal damage, and hemorrhage levels increased after SCI compared to Group C. These histological markers increased after SCI and decreased after BA+SCI. BA was found to reduce SCI-induced oxidative stress and oxidative stress-induced apoptosis.Conclusion: BA administered before SCI was shown to be more effective in protecting neural damage.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Boric acid, Neuroprotective, Oxidative stress, Spinal cord injury
نویسندگان مقاله | Turan Kandemir
Department of Neurosurgery, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey


| İbrahim Söğüt
Department of Biochemistry, Demiroglu Bilim University, Medical Faculty, Istanbul, Turkey


| Zeki Ataizi
Department of Neurosurgery, Eskişehir Yunus Emre State


| Betül Can
Department of Medical Biochemistry, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey


| Ayşegül Oğlakçı İlhan
Department of Medical Laboratory Techniques, Eldivan Health Services Vocational School, Cankırı Karatekin University, Cankırı, Turkey


| Dilek Burukoglu Donmez
Department of Histology and Embryology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey


| Güngör Kanbak
Department of Medical Biochemistry, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25270.html
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نوع مقاله منتشر شده Original Article
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