این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۴، صفحات ۴۸۶-۴۹۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Glutamate receptors within the lateral periaqueductal gray (lPAG): Effects on blood pressure and heart rate in basic and hypotensive hemorrhagic rats
چکیده انگلیسی مقاله Objective(s): The lateral periaqueductal gray (lPAG) is involved in regulating cardiovascular activity. As glutamate is present in this region, the effect of glutamatergic receptors on cardiovascular functions in basic and hypotensive hemorrhagic (Hem) rats was investigated.Materials and Methods: In both basic and hemorrhagic animals, saline, L-glutamate (L-Glu), and ionotropic receptor antagonists (MK-801 and GYK as NMDA and non-NMDA receptor antagonists, respectively) with and without L-Glu microinjected into the lPAG. The heart rate (HR), mean arterial pressure (MAP), and systolic blood pressure (SBP) were captured, and those changes (Δ) were calculated and analyzed.Results: The results showed that in basic conditions, microinjection of MK-801 and GYK alone did not significantly affect cardiovascular parameters, but L-Glu significantly increased all parameters (P<0.001). However, co-injection of GYK and L-Glu significantly attenuated cardiovascular responses induced by L-Glu (P<0.01), whereas MK-801 did not have effects. In Hem hypotensive condition, injection of MK-801 and GYK alone could not significantly change the cardiovascular responses, while L-Glu alone significantly increased these responses (P<0.001). In this condition, Co-injection of L-Glu with GYK attenuates the pressor effect of L-Glu, but MK-801 did not affect it. Conclusion: Findings suggest an excitatory cardiovascular role of the glutamatergic system of lPAG in normotensive conditions mediated by a non-NMDA receptor. However, in hem hypotensive conditions, the endogenous glutamatergic system of lPAG does not affect hem hypotension, while exogenous glutamate via a non-NMDA receptor could improve cardiovascular responses in this condition. 
کلیدواژه‌های انگلیسی مقاله Cardiovascular system, Glutamate, Hemorrhage, Lateral periaqueductal gray, Non-NMDA receptor
نویسندگان مقاله | Vida Alikhani
Department of Physiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran


| Reza Mohebbati
Department of Physiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran|Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Naser Shafei
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25563.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات