این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۴، صفحات ۵۰۷-۵۱۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways
چکیده انگلیسی مقاله Objective(s): Diclofenac (Diclo) is a therapeutic agent used in the treatment of pain and inflammatory diseases, but it is also toxic to the human body. Morin is a flavonoid found naturally in plants and has many biological and pharmacological activities, including anti-inflammatory, anti-oxidant, and anticancer activities. This study aimed to investigate the efficacy of Morin in Diclo-induced testicular toxicity. Materials and Methods: Morin (50 mg/kg and 100 mg/kg) was administered orally for five days, while Diclo was administered intraperitoneally at 50 mg/kg on days 4 and 5. Biochemical, molecular, and histological methods were used to investigate oxidative stress, inflammation, apoptosis, and endoplasmic reticulum (ER) stress damage indicators in testicular tissue. Results: Morin treatment attenuated Diclo-induced oxidative stress damage by increasing anti-oxidant levels (SOD, CAT, GPx, GSH, Nrf-2, HO-1, and NQO1) and decreasing MDA levels, an indicator of lipid peroxidation. Morin reduced levels of the inflammatory mediators NF-κB protein. Increases in apoptotic Bax and Caspase-3 by Diclo were reduced by Morin, while decreased antiapoptotic Bcl-2 level was increased. Morin reduced Diclo-induced ER stress injury by decreasing ATF-6, PERK, IRE1, GRP-78, and CHOP levels. Also, Diclo decreased COX-2 levels.Conclusion: Overall, Morin may be an effective treatment of choice for testicular tissue damage associated with Diclo toxicity and may reduce the level of damage.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Diclofenac, Endoplasmic reticulum stress, Inflammation, Morin, Oxidative stress
نویسندگان مقاله | Hasan Şimşek
Department of Physiology, Faculty of Medicine, Aksaray University, Aksaray, Türki̇ye


| Nurhan Akaras
Department of Histology and Embryology, Faculty of Medicine, Aksaray University, Aksaray, Türki̇ye


| Cihan Gur
Department of Medical Laboratory Techniques, Vocational School of Health Services, Atatürk University, Erzurum, Türki̇ye


| Sefa Kucukler
Department of Veterinary Biochemistry, Faculty of Veterinary, Atatürk University, Erzurum, Türki̇ye


| Mustafa Ileriturk
Department of Animal Science, Horasan Vocational College, Atatürk University, Erzurum, Türki̇ye


| Fatih Kandemir
Department of Medical Biochemistry, Faculty of Medicine, Aksaray University, Aksaray, Türki̇ye
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25503.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات