این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Toxicology، جلد ۱۹، شماره ۱، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Cadmium-induced Reproductive Toxicity in Male Wistar Rats: Ameliorative effect of a Polyherbal Remedy, STC30
چکیده انگلیسی مقاله Background: Cadmium-induced male infertility is associated with oxidative stress. There are however no literature on its effect on Cadmium-induced male reproductive toxicity and hence this.
Methods: Twenty male wistar rats were separated into four groups of 5 rats each namely; control, Cadmium-only, STC30-only and Cadmium+STC30. Daily administration was for 28 days after which blood and testicular samples collected for determination of relevant parameters.
Results: The results showed significant body weight decrease in the Cadmium-only group compared with the control, Cadmium+STC30 and STC30-only (p<0.05). Testicular and epididymal weights were significantly reduced in the Cadmium-only compared with control, STC30-only and Cadmium+STC30 groups (p<0.05). Sperm count, viability and motility were significantly reduced in the Cadmium-only compared with the control (p<0.05) STC30-only and Cadmium+STC30 (p<0.05). Teratozotospermia was significantly elevated in the Cadmium-only compared with the control, Cadmium+STC30 and STC30-only  (p<0.05). Gonadotropin-releasing hormone, follicle stimulating hormone, luteinizing hormone and testosterone were significantly reduced in the Cadmium-only compared with the control groups (p<0.05). Testicular malomdialdehyde and TBARS were significantly increased in the Cadmium-only (p<0.05) compared with the control, STC30-only and STC30+Cadmium (p<0.05). Superoxide dismutase, glutathione peroxidase, catalase activities and total antioxidant capacity in testes were significantly (p<0.05) reduced in the Cadmium-only compared with the control, STC30-only and Cadmium+STC30 groups. Sections of the testes showed significantly reduced Johnsen score in the Cadmium-only and Cadmium+STC30 groups compared with control (p<0.05), higher in STC30-only and Cd+STC30 than Cadmium-only. In conclusion, STC30 ameliorates Cadmium-induced male reproductive toxicity and oxidative stress in Wistar rats.
 
کلیدواژه‌های انگلیسی مقاله STC30, Cadmium, male rats, reproductive parameters, ameliorates
نویسندگان مقاله | Justina Nwangwa
Department of Physiology, University of Calabar, Calabar, Nigeria.


| Ekpe Aribo
Department of Physiology, University of Calabar, Calabar, Nigeria.


| Augustine Udefa
Department of Physiology, University of Calabar, Calabar, Nigeria.


| Atim Antai
Department of Physiology, University of Calabar, Calabar, Nigeria.
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1242-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده عمومی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات