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Iranian Journal of Microbiology، جلد ۱۷، شماره ۱، صفحات ۱۹-۲۴
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عنوان انگلیسی Ceftazidime-avibactam susceptibility against Escherichia coli and Klebsiella pneumoniae
چکیده انگلیسی مقاله Background and Objectives: Carbapenem-resistant Enterobacteriaceae (CRE) infections are extremely difficult to treat and have a high fatality rate. The study's primary goal was to determine the rate of ceftazidime-avibactam susceptibility using disc diffusion and E-Test, as well as to evaluate the agreement between the two methods. Materials and Methods: A total of 124 multidrug-resistant (including carbapenem) Escherichia coli and Klebisella pneumoniae isolates were included. Kirby Bauer's disc diffusion and E-test were used as the testing methods in this study. Results: In this study 37.5% and 33.9% of the isolates were susceptible to ceftazidime-avibactam by E test and Disc diffusion respectively. There were five isolates which produced discordant results. Among the 56 isolates there was 91% agreement between the two methods. Conclusion: Among the discordant isolates the alarming disparity in zone size was a significant concern. Since CRE infections are very common, an economical and practical method for testing ceftazidime-avibactam susceptibility is needed in all the clinical microbiology laboratories as it is a last resort drug.
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نویسندگان مقاله | Arun Sachu
Department of Microbiology, Believers Church Medical College, Thiruvalla, Kerala, India


| Alice David
Head of Medical Research, Believers Church Medical College, Thiruvalla, Kerala, India
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4901
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