این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Microbiology، جلد ۱۷، شماره ۱، صفحات ۱۴۴-۱۵۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Exploring the antimicrobial potential of two haloarchaeal strains belonging to the genera Halopiger and Natrialba isolated from the Algerian Sahara
چکیده انگلیسی مقاله Background and Objectives: Halophilic archaea commonly produce antimicrobial peptides (halocins), but only a few studies have been conducted on these molecules. This study explores the antimicrobial potential of two strains belonging to Halopiger and Natrialba genera, isolated from hypersaline environments in the Algerian Sahara. Antimicrobial compounds produced by these genera have rarely been studied before. Materials and Methods: The antimicrobial activity of the strains was evaluated, along with the effects of UV radiation and culture conditions on growth and compound production. Stability assays and the effects of extracted compounds on target cells and peripheral blood mononuclear cells (PBMC) were assessed. Results: The strains exhibited high anti-archaeal activities and cross-domain interactions. Producing extracellular compounds associated with halocin, in the cell-free supernatant (CFS). These compounds remained stable at different temperatures (4°C, 60°C, 80°C, and 100°C) and different pH ranges (4-10 and 5-11), with antimicrobial profiles changed in response to UV light. The active compounds resembled known halocins but displayed unique features suggesting the discovery of new halocins. Additionally, Natrialba extracts showed significant activity against PBMC. Conclusion: This investigation confirms that Algerian saline soils are a promising source of interesting antimicrobial compounds.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Inès Quadri
Department of Cellular and Molecular Biology, Cellular and Molecular Biology Laboratory (Team Microbiology), University of Sciences and Technology Houari Boumediene, Bab Ezzouar, Algiers, Algeria


| Imene Hassani
Department of Cellular and Molecular Biology, Cellular and Molecular Biology Laboratory (Team Microbiology), University of Sciences and Technology Houari Boumediene, Bab Ezzouar, Algiers, Algeria


| Hocine Hacène
Department of Cellular and Molecular Biology, Cellular and Molecular Biology Laboratory (Team Microbiology), University of Sciences and Technology Houari Boumediene, Bab Ezzouar, Algiers, Algeria
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4725
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات