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Iranian Journal of Public Health، جلد ۵۴، شماره ۲، صفحات ۳۶۱-۳۶۹
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عنوان انگلیسی Exploring the Association between Childhood Asthma and Abnormal Spermatozoa: An Analysis Using Mendelian Randomization
چکیده انگلیسی مقاله Background: Childhood asthma ranks among the prevailing chronic respiratory conditions affecting a significant number of individuals. The long-term hypoxic state and chronic inflammatory state caused by asthma could be linked with spermatozoa apoptosis. However, the correlation between childhood asthma and abnormal spermatozoa is currently unknown. Methods: In our study, the method of two-sample Mendelian randomization (2SMR) was used by searching an appropriate European population genome-wide association studies (GWAS) database of childhood asthma and abnormal spermatozoa from the Ieu Open GWAS Project database. Sixteen related single-nucleotide polymorphisms (SNPs) were screened as instrumental variables (IV). Subsequently, we employ various statistical methods including inverse variance weighting (IVW), weighted median method (WME), MR-Egger regression, Simple mode, and Weighted mode to investigate the causal link between childhood asthma and the development of abnormal spermatozoa. Results: Based on IVW results, childhood asthma is not an independent risk factor for abnormal sperm formation (P=0.14). Other statistical models such as WME, MR-Egger regression, Simple mode, and weighted mode also showed the same results. Leave-one-out sensitivity analysis and heterogeneity test were conducted and no horizontal pleiotropy was found. Conclusion: There was no causal relationship between childhood asthma and abnormal spermatozoa formation at the genetic level.
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نویسندگان مقاله | Qian Zhang
1. Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China 2. Department of Child Health, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China


| Yao Ge
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China


| Yuan Chen
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China


| Yun Zhang
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China


| Xiaoyan Xie
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China


| Jian Yu
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China


| Yunlei Bao
Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China


| Feng Jiang
Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China


| Chuyan Wu
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/34991
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