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Iranian Journal of Blood and Cancer، جلد ۱۶، شماره ۴، صفحات ۴۷-۵۵
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Analysis of Coagulation Parameters in Patients with Breast Pathology and Their Possible Relevance to a Hypercoagulable State
چکیده انگلیسی مقاله
Background: To study the alteration in coagulation parameters such as activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), D-dimer and fibrinogen among patients with benign and malignant breast lesions when compared to normal controls.
Materials and methods: The present study was a prospective cross-sectional study conducted among 50 cases diagnosed with benign and malignant breast cancer and comparing them with 20 age-matched controls. Coagulation parameters such as PT, TT, APTT, fibrinogen, and D-dimer were collected and compared between the malignant cases, benign cases, and age-matched control groups based on clinical and demographic details, the status of Progesterone receptor, Estrogen receptor, Her2 Neu, side and grading of cancer.
Results: Significant difference was reported with regard to mean age (p=0.0103) between malignant and benign tumor group (p=0.0103). Mean fibrinogen (p<0.001), thrombin time (p=0.007), and D-dimer (p<0.001) between the three groups also showed a statistically significant difference.
Conclusion: Of the biological parameters assessed in the present study; thrombin time, D-dimer and fibrinogen levels show significant differences in patients with benign and malignant breast diseases. This may serve as a biological marker to evaluate the beginning of Cancer-associated venous thrombosis (CAT) in breast cancer patients.
کلیدواژه‌های انگلیسی مقاله Biomarkers, Blood coagulation, Breast neoplasm, Fibrin fragments, Thrombosis
نویسندگان مقاله | Nidhya Ganesan
Department of Pathology, PSG Institute of Medical Sciences and Research, Off, Avinashi Rd, Peelamedu, Coimbatore, Tamil Nadu 641004.


| Stefan Mariano
Department of Pathology, PSG Institute of Medical Sciences and Research, Off, Avinashi Rd, Peelamedu, Coimbatore, Tamil Nadu 641004.


| R Chitra
Department of Surgery, PSG Institute of Medical Sciences & Research, Avinashi Rd, Peelamedu, Coimbatore, Tamil Nadu 641004.


| Prasanna N Kumar
Department of Pathology, PSG Institute of Medical Sciences and Research, Off, Avinashi Rd, Peelamedu, Coimbatore, Tamil Nadu 641004.
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-1246-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Adults Hematology & Oncology
نوع مقاله منتشر شده پژوهشی
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