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Iranian Journal of Pathology، جلد ۲۰، شماره ۱، صفحات ۱-۱۷
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عنوان انگلیسی Vacuolating Cytotoxin A (VacA) and Extracellular Vesicles in Helicobacter pylori: Two Key Arms in Disease Development
چکیده انگلیسی مقاله Extracellular vesicles (EVs) are cell-derived vesicles that play a critical role in host-pathogen interactions, facilitating intercellular communication and transporting both pathogen- and host-derived molecules during infection spread. To regulate their environment, for instance, by modulating innate and adaptive inflammatory immune responses, pathogens may alter the composition of EVs produced by infected cells. Gastric cancer is one of the leading causes of cancer-related deaths worldwide, and Helicobacter pylori infection is considered a significant risk factor for its development. This cancer is characterized by significant inflammation mediated by EVs generated from infected host cells. H. pylori contributes substantially to inflammation, promoting disease progression. Moreover, H. pylori produces and releases vesicles known as outer membrane vesicles (H. pylori-OMVs), which contribute to the shrinkage and cellular transformation of the gastric epithelium. Although the vacuolating cytotoxin A (VacA) plays a critical role in pathogenesis, its association with EVs in H. pylori has not been previously addressed. Understanding the roles of extracellular vesicles and VacA during H. pylori infection—whether they benefit the host or the pathogen—could pave the way for new treatment approaches. This review briefly discusses the role of VacA and extracellular vesicles in the growth and pathogenesis of H. pylori.
کلیدواژه‌های انگلیسی مقاله Helicobacter disease,Extracellular vesicles, Disease development,autophagy,Cell Signaling,Immune cells
نویسندگان مقاله Seyedeh Faride Alavi Rostami |
Department of Microbiology, Faculty of Biological Sciences, Islamic Azad University Tehran-North Branch, Tehran, Iran

Mansoor Khaledi |
Department of Microbiology and Immunology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

Fatemeh Dalilian |
Department of Microbiology, Mashhad University of Bacic science, Mashhad, Iran

Mahtab Mehboodi |
Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Atefeh Akbari |
Department of Microbiology, Faculty of Science, Qom branch, Islamic Azad University, Qom, Iran

Milad Shahini Shams Abadi |
Department of Microbiology and Immunology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

Pouria Khodaei Ataloo |
Department of Microbiology, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran

Zeinab Mohsenipour |
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Samad Rastmanesh |
Department of Bacteriology and Virology, School of Medicine, Tabriz University of Medical Science, Tabriz, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_720997_4657f809dceb3b9934e54d790ef42f8e.pdf
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