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Iranian Journal of Pathology، جلد ۲۰، شماره ۱، صفحات ۱۸-۲۳
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عنوان انگلیسی Exploring the Significance of Eosinophil Infiltration for Psoriasis Diagnosis: A Cross-sectional Analysis
چکیده انگلیسی مقاله Background & Objective: There is a discrepancy in the findings concerning the involvement of eosinophils in the pathogenesis of psoriasis. This study aims to assess the quantity of eosinophils in pathological specimens obtained from individuals diagnosed with psoriasis.
Methods: In this investigation, a cross-sectional and retrospective study design was employed, involving the analysis of 91 skin samples obtained from patients diagnosed with psoriasis. Two experienced dermatologists thoroughly reviewed the specimens' demographic characteristics, clinical features, and pathological attributes. Subsequently, eosinophils were quantified by counting these cells within all microscopic fields, utilizing a magnification of 200. 
Results: The findings of this study revealed that eosinophils were present in approximately 70.3% of the examined samples, with a mean eosinophil count of 2.42±0.63. Although no significant correlation was observed between the clinical subtype and the average eosinophil count, eosinophils were most commonly detected in cases of generalized pustular psoriasis (100%) and vulgaris types (71.11%). Notably, patients exhibiting Munro's microabscess and dilated papillary dermal blood vessels exhibited a significantly higher number of eosinophils (P=0.007 and P=0.039, respectively). Additionally, a notable association was identified between the presence of spongiosis and eosinophil counts in the pathological samples (P=0.04).
Conclusion: The presence of eosinophils does not contradict the diagnosis of psoriasis. Furthermore, a notable association was observed between the count of eosinophils and the presence of spongiosis, dilated dermal papillary vessels, and Munro's microabscess.
کلیدواژه‌های انگلیسی مقاله Eosinophil,pathology,Psoriasis
نویسندگان مقاله Maryam Khalili |
Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran

Afsaneh Kooshesh |
Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran

Simin Shamsi Meymandi |
Pathology and Stem Cells Research Center, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Niloofar Mehrolhasani |
Pathology and Stem Cells Research Center, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Rezvan Amiri |
Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran

Mohammad Rezaei Zadeh Rukerd |
Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Mahin Aflatoonian |
Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_720998_50781cac55120029a656713f482c1798.pdf
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