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Iranian Journal of Pathology، جلد ۲۰، شماره ۱، صفحات ۴۲-۴۸
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عنوان انگلیسی Evaluation of Serum CTRP-4 and CTRP-12 Levels in Hashimoto's Thyroiditis Patients: A Comparative Analysis with a Control Group and Their Correlation with Biochemical Factors
چکیده انگلیسی مقاله Background & Objective: Hashimoto's thyroiditis (HT) is one of the most common thyroid disorders and is characterized by manifestations attributed to thyroid gland damage and inflammatory conditions. Disturbances in thyroid hormones have physiological effects on lipoprotein metabolism and liver enzymes. CTRP family: C1q/TNF-related protein (CTRP) is an adipokine superfamily of proteins. Its essential role is anti-inflammatory activation, insulin sensitization, and regulation of blood lipids. In this study, we investigated the levels of CTRP-4 and CTRP-12 in the serum of HT patients and determined their association with biochemical factors.
Methods: The study included 60 participants, divided into HT patients and control groups. Diagnostic criteria for HT patients included anti-thyroid peroxidase antibodies (anti-TPO)>50 IU/mL. Serum levels of CTRP-4, CTRP-12, and anti-TPO were measured using an Enzyme-Linked Immunosorbent Assay.
Results: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than in the control groups (P=0.012 and P=0.003, respectively). HT patients also exhibited higher fasting blood glucose (FBG), cholesterol, TG, HDL, and LDL serum levels. Spearman's correlation analysis revealed a positive association between serum levels of CTRP-4 and CTRP-12 and anti-TPO (respectively, r= 0.295, P=0.022 and r = 0.346, P=0.007).
Conclusion: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than those in the control groups. These factors probably play a role in the pathogenesis of Hashimoto's thyroiditis. The clinical significance of these factors should be evaluated in future studies.
کلیدواژه‌های انگلیسی مقاله Anti-TPO,Autoimmune diseases,CTRP-4,CTRP-12,biochemical factors,Hashimoto Thyroiditis
نویسندگان مقاله Doaa Jawad Al-Husseini |
Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Mohsen Saravani |
Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Shahin Nosratzehi |
Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Hamideh Akbari |
Clinical Research Development Unit, Sayad Shirazi Hospital, Golestan University of Medical Science, Gorgan, Iran

Afsaneh Shafiei |
Department of Clinical Biochemistry, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran

Seyyed Mehdi Jafari |
Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_721052_7d472263a4b7c3838101e46541e7b740.pdf
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