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Iranian Journal of Pathology، جلد ۲۰، شماره ۱، صفحات ۵۸-۶۷
عنوان فارسی
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عنوان انگلیسی An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma
چکیده انگلیسی مقاله Background & Objective: Even though fast advances in the detection and management of bladder carcinoma, the number of deaths remains high. Therefore, the identification of an effective biomarker predicting tumor progression in cancer bladder patients is a crucial issue. This study aims to identify TIPE2 and CD36 expressions in cancer bladder and examine their relationship with clinicopathological data and prognosis.
Methods: Using immunohistochemistry, we investigated 60 specimens of bladder urothelial cancer (UC) for the expression of TIPE2 and CD36 and compared them with clinicopathologic parameters and survival data. Furthermore, we investigate the association between TIPE2 and CD36 expression and Vimentin expression to elucidate the influence of TIPE2 and CD36 on the epithelial-mesenchymal transition (EMT) in UC.
Results: TIPE2 expression was associated with lower stages and prolonged disease-free survival (DFS) and overall survival (OS). Therefore, TIPE2 may be considered a good indicator of UC prognosis. CD36 immuno-positivity was associated with high tumor grade, stages, shorter OS, and DFS. Therefore, the immune positivity of CD36 may be a poor prognostic marker for UC patients. Furthermore, Vimentin expression was directly correlated with CD36 expression and inversely correlated with TIPE2 expression.
Conclusion: TIPE2 and CD36 may be novel biomarkers for predicting tumor metastasis and prognosis in patients with bladder UC and hold promise as therapeutic targets.
کلیدواژه‌های انگلیسی مقاله Urothelial carcinoma,TIPE2,CD36,Immunohistochemistry,epithelial-mesenchymal transition,Prognosis
نویسندگان مقاله Amira M. Abd El Maged |
Pathology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt

Nahla Mustafa Badr |
Pathology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt

Hanan Lotfy Mohamed |
Department of pathology, Faculty of Medicine, Zagazig University, Egypt

نشانی اینترنتی https://ijp.iranpath.org/article_721054_7200e8eb7fea80a7e0723eb52173ea97.pdf
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