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Iranian Journal of Pathology، جلد ۲۰، شماره ۱، صفحات ۹۸-۱۰۶
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Value of Cytological Diagnosis in Pancreatic Endoscopic Ultrasound-guided Fine Needle Aspiration: Comparing Accuracy in Common Epithelial Pancreatobiliary Tumors and Evaluating the Significance of Cell Bloc
چکیده انگلیسی مقاله Background & Objective: Only limited literature describes the accuracy of endoscopic ultrasonography–fine needle aspiration (EUS-FNA) cytology in different types of pancreatic epithelial tumors, underscores the usefulness of cell blocks, and discusses potential diagnostic pitfalls.
Methods: This study included 108 patients who underwent EUS-FNA pancreatobiliary cytology followed by surgery. Age, gender, tumor location, tumor size, presence or absence of a cell block, cytologic and pathologic diagnoses, and histologic tumor grade were recorded. Cytology and pathology slides were examined, and the cytologic accuracy was determined by comparing cytology results with histopathology as the gold standard. Additionally, the impact of cell block on cytologic accuracy was assessed.
Results: EUS-FNA cytology showed an overall accuracy of 80%, a sensitivity of 90%, and a false-positive rate below 1%. Pancreatic ductal adenocarcinomas (PDAs) accounted for 65% of cases, followed by neuroendocrine tumors (NETs), solid pseudopapillary neoplasms (SPNs), mucinous cystic neoplasms (MCNs), and chronic pancreatitis. Diagnostic accuracy was higher for PDA and SPN than for NET and MCN and significantly improved to 100% in cases with a cell block.
Conclusion: Combining pancreatobiliary cytology with a cell block leads to a marked increase in diagnostic accuracy, reaching 100%. In addition, poorer-grade PDAs and well-differentiated organoid-type tumors, such as NETs and SPNs, exhibit higher diagnostic accuracy.
کلیدواژه‌های انگلیسی مقاله accuracy,Cytology,EUS-FNA,Pancreatic adenocarcinoma,Pancreatobiliary
نویسندگان مقاله Naser Rakhshani |
Department of Pathology, Gastrointestinal and liver disease Research center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

Neda Soleimani |
Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

Sanaz Aghaei |
Department of Pathology, Iran Medical School, Iran University of Medical Sciences, Tehran, Iran

Rasha Barakat |
Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

Ali Mohammad Keshtvarz Hesam Abadi |
Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_721059_257f784c2c46d5674f7d9b8a4a1014ae.pdf
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