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Iranian Journal of Pathology، جلد ۲۰، شماره ۱، صفحات ۱۱۷-۱۲۴
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عنوان انگلیسی Molecular Characterization of Aminoglycoside-modifying Enzymes (AMEs) in Aminoglycoside-Resistant Staphylococcus aureus: A Cross-sectional Study in Northeastern Iran
چکیده انگلیسی مقاله Background & Objective: The resistance genes encoding aminoglycoside-modifying enzymes (AMEs) are now widely prevalent in different populations of Staphylococcus aureus. The study aimed to determine the frequency of AMEs-encoding genes in clinical isolates of S. aureus.
Methods: A total of 105 S. aureus isolates were obtained from the different clinical samples; and then were identified by conventional biochemical tests. The antibiotic resistance patterns of the isolates were characterized by the agar disk diffusion method. The distribution of the AMEs and femA genes was determined by conventional and multiplex PCR.
Results: The aminoglycoside resistance rates of kanamycin, tobramycin, gentamicin, amikacin, and netilmicin were 47.6%, 46.6%, 45.7%, 45.7%, and 26.6%, respectively. 16.1% and 1.9% of isolates were MDR and XDR phenotypes, respectively. 21.9% of S. aureus isolates harbored the femA gene and were determined as methicillin-resistant S. aureus (MRSA) clones. The aac(6')/aph(2'') was the most prevalent (47.8%) AME-encoding gene in aminoglycoside-resistant S. aureus, followed by ant(4')-Ia (30.4%) and aph(3')-IIIa (21.7%).
Conclusion:Our study demonstrated that the coexistence of several AMEs and the spread of the resistance determinants like femA in S. aureus clinical isolates are alarming and may contribute to the broadening of aminoglycoside resistance spectra and limit treatment options for staphylococcal infections.
کلیدواژه‌های انگلیسی مقاله AMEs-encoding genes, Aminoglycoside, Drug resistance, FemA,Staphylococcus aureus
نویسندگان مقاله Malihe Naderi |
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Neda Yousefi Nojookambari |
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Somayeh Talebi |
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Mohammad Reza Mohammadi |
Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Sajjad Yazdansetad |
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_721061_0c485f81d840ac0733156db745c7d053.pdf
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