این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۲، صفحات ۹۳۳-۹۴۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Exploring the anti-inflammatory effects of Lavandula stoechas L. extract on ovalbumin-induced acute asthma in BALB/c mice
چکیده انگلیسی مقاله Objective: Asthma is an inflammatory disease of the respiratory system affecting over 300 million people worldwide. Lavandula stoechas L. (L. stoechas) has traditionally been used to manage inflammatory diseases and against multiple medical conditions. In this study, we aimed to explore the anti-inflammatory effects of the hydro-alcoholic extract of L. stoechas in a mice model of acute asthma.Materials and Methods: Thirty-five male BALB/c mice were placed into five distinct study groups: (1) control, (2) ovalbumin (OVA) + Al(OH)3, (3) OVA + L. stoechas (200 mg/kg), (4) OVA + L. stoechas (300 mg/kg) and (5) OVA + dexamethasone. Sensitization of the mice involved intraperitoneal administration of 75 µg OVA + 2mg Al(OH)3 on days 1 and 8. Subsequently, between days 15 and 17, the mice underwent intranasal challenges with 50 µg of OVA. On days 13–18, the mice were administered either L. stoechas (200 and 300 mg/kg) orally or dexamethasone intraperitoneally (used as a positive control). On day 19, both bronchoalveolar lavage (BAL) fluid and lung tissue samples were collected for biochemical and immuno-histological analyses.Results: The L. stoechas extract-treated groups displayed notable reductions in histological alterations and inflammatory cell infiltration, surpassing the effects observed in the OVA group. Moreover, the L. stoechas treatment group exhibited lowered TNF-α and IL-6 expression levels.Conclusion: Our results demonstrated the potential of L. stoechas as an anti-inflammatory agent in acute asthma.
کلیدواژه‌های انگلیسی مقاله Acute asthma, Anti-inflammatory, Lavandula stoechas L, Ovalbumin
نویسندگان مقاله | Nafiseh Erfanian
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Faezeh Fazlpour
Student Research Committee, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran


| Hossein Safarpour
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Sayyedeh Fatemeh Askari
Department of Pharmacognosy and Traditional Pharmacy, School of Pharmacy, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Mohsen Foadoddini
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Saeed Nasseri
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_25175.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short communication
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات