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Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۲، صفحات ۱۰۵۹-۱۰۶۹
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عنوان انگلیسی The effects of carvacrol on the cardiac apoptosis gene expression levels in heart tissue of obese male rats induced by high-fat diet
چکیده انگلیسی مقاله Objective: Animal studies have revealed that lipid accumulation in obese mice fed with a high-fat diet (HFD) leads to alterations in the structural and functional properties of cardiovascular tissues. The current study aimed to investigate apoptosis/anti-apoptotic markers in the heart tissue of rats fed with a HFD.Materials and Methods: Twenty-four male Wistar rats (weighing approximately 180 grams) were randomly divided into three groups (n=8 each group), including the control group (C), the high-fat diet group (HFD), and the high-fat diet + carvacrol group (HFD + Carva). Animals received a standard or HFD to induce obesity for three months. From day 61 to 90 in the HFD+Carva group, carvacrol was injected intraperitoneally (50 mg/kg) every other day. At the end of the study, the heart tissue was examined for pathological changes and the mRNA levels of TNF-α, Bcl2, Bax, and caspase3 in the heart tissue by Real Time-PCR.Results: HFD-induced obesity led to increased TNF-α, caspase-3, and Bax and decreased Bcl-2 expression levels in heart tissue. Furthermore, histopathological changes in intracytoplasmic vacuole accumulation were evident in the HFD-obese animals. Carvacrol treatment significantly decreased the expression of Bax, TNF-α, and caspase-3 and increased the expression of Bcl-2 in heart tissue.Conclusion: In the findings, carvacrol was found to decrease the histopathological changes caused by HFD in heart tissue by suppressing the expression of genes involved in the apoptosis pathway.
کلیدواژه‌های انگلیسی مقاله High-fat diet, Obesity, Carvacrol, Apoptosis, Heart tissue
نویسندگان مقاله | Mahdi Ahmadi
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Sadegh Bagherzadeh
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran


| Mohammad Hossein Boskabady
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Ali Vahabi
Department of Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Sakhavat Abolhasani
Department of Basic Sciences and Health, Sarab Faculty of Medical Sciences, Sarab, East Azerbaijan, Iran


| Mohammad Reza Aslani
Department of Physiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_25089.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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