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Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۲، صفحات ۱۰۷۰-۱۰۸۱
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عنوان انگلیسی Investigating the effect of a herbal cream containing rose essence in an animal model of eczema
چکیده انگلیسی مقاله Objective: Eczema, a common inflammatory skin condition characterized by itching and dermatitis, can significantly impact the quality of life. While conventional treatments exist, there is interest in exploring natural alternatives. This study investigates the efficacy of a rosehip extract-based cream in mitigating eczema symptoms in a mouse model.Materials and Methods: Thirty-five mice were divided into five groups: control, dinitrochlorobenzene (DNCB)-induced eczema (model group), and treatment groups receiving placebo, betamethasone cream (positive control), or rosehip extract cream. Following topical treatment for four weeks, the animals were euthanized, and their skin was evaluated for inflammation, moisture, and thickness. Histopathological analysis was performed using hematoxylin and eosin (H&E) staining.Results: Compared to the control group, DNCB treatment significantly increased inflammation, erythema (redness), dryness, and epidermal thickness. Notably, topical application of the rosehip extract cream significantly reduced these eczema-associated parameters, demonstrating efficacy comparable to the positive control (betamethasone cream).Conclusion: This study suggests that a topical cream formulated with rosehip extract may be a promising therapeutic strategy for alleviating eczema symptoms. The anti-inflammatory and potentially regenerative properties of rose extract warrant further investigation for the development of natural eczema treatments.
کلیدواژه‌های انگلیسی مقاله eczema, Rose extract, Dinitrochlorobenzene, Small laboratory mouse, Rosa Spp
نویسندگان مقاله | Ali Reza Malayeri
Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Anayatollah Salimi
Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Fariba Iraji
Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Susan Sabbagh
Department of Anatomical Sciences, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran


| Neda Shakerian
Department of Clinical Biochemistry, Faculty of Medical Sciences, Dezful University of Medical Sciences, Dezful, Iran


| Mobin Khaledi
Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_25132.html
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نوع مقاله منتشر شده Original Research Article
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