این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۵، صفحات ۵۶۵-۵۷۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Investigation of the molecular and cellular effects of Shilajit on 5-fluorouracil (5-FU)-induced nephrotoxicity in rats
چکیده انگلیسی مقاله Objective(s): This study aimed to evaluate the protective effects of shilajit on 5-fluorouracil (5-FU)-induced nephrotoxicity in a rat model.Materials and Methods: Twenty male Sprague Dawley rats were divided into four groups: Control, 5-FU, shilajit, and 5-FU + shilajit. 5-FU was administered intraperitoneally at 200 mg/kg, while shilajit was given orally at 200 mg/kg. Kidney tissues were analyzed for oxidative stress markers, protein expression (SIRT2, SIRT3, β-catenin, E-cadherin, and caspase-3), and histopathological changes.Results: 5-FU significantly increased oxidative stress parameters and kidney damage markers. Shilajit co-administration with 5-FU reduced oxidative stress and increased anti-oxidant status and SIRT2, SIRT3, and cell adhesion protein expression. Histopathological evaluation showed reduced renal damage in the shilajit + 5-FU group compared to the 5-FU group.Conclusion: Shilajit exhibited significant protective effects against 5-FU-induced nephrotoxicity, improving oxidative parameters, protein expression, and kidney histopathology. Further studies are needed to elucidate its molecular mechanism and therapeutic potential.
کلیدواژه‌های انگلیسی مقاله Caspase 3, Fluorouracil, Resins, Plant, Nephrotoxicity, Sirtuin 2, Sirtuin 3
نویسندگان مقاله | Mehmet Ezer
Kafkas University Medical School, Department of Urology, Kars, Türkiye


| Melek Öztürkler
Kafkas University Department of Chemistry, Faculty Science and Letter, Kars, Türkiye


| Kezban Yıldız Dalgınlı
Department of Chemistry and Chemical Processing Technologies, Kars Vocational High School Kafkas University, Kars, Türkiye


| Emine Atakisi
Kafkas University, Faculty of Veterinary Medicine, Department of Biochemistry, Kars, Türkiye


| Hatice Beseren Havadar
Kafkas University Health Research and Application Hospital, Pathology Laboratory, Kars, Türkiye


| Onur Atakisi
Kafkas University Department of Chemistry, Faculty Science and Letter, Kars, Türkiye
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25470.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات