این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۵، صفحات ۶۱۲-۶۱۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Nephroprotective impact of royal jelly against rhabdomyolysis-induced kidney damage in rats
چکیده انگلیسی مقاله Objective(s): The current work aimed at studying the impact of royal jelly on kidney damage caused by rhabdomyolysis in male rats.Materials and Methods: 40 male rats were randomly assigned to five groups of eight: control, rhabdomyolysis, and rhabdomyolysis, administered with three doses of royal jelly (RJ) (100, 200, and 400 mg/kg) for seven days. On the fifth day, we injected glycerol intramuscularly to induce rhabdomyolysis. Researchers examined serum biochemical parameters, inflammation, oxidative stress, apoptosis, and kidney tissue injury.Results: As a result of injecting glycerol, serum levels of creatinine, urea, and creatine phosphokinase were considerably elevated. The concentration of inflammatory mediators, as well as the expression of apoptotic parameters, was significantly elevated after glycerol injection. The percentage of kidney tissue damage and neutrophil gelatinase-associated lipocalin expression also increased significantly. Oral usage of RJ (100, 200, and 400 mg/kg) caused a decline in serum CPK, tissue level of total thiols, catalase activity, and renal expression of   BAX compared to the rhabdomyolysis group. Serum creatinine and NGAL expression were also significantly reduced by the RJ (200 and 400 mg/kg). RJ significantly reduced the concentration of inflammatory mediators at 100 and 200 mg/kg doses and the expression of bcl2 by RJ at 100 and 400 mg/kg doses.  Conclusion: Royal jelly safeguards the kidney from rhabdomyolysis-related damage, primarily through its anti-oxidant, anti-apoptotic, and anti-inflammatory effects.
کلیدواژه‌های انگلیسی مقاله Acute kidney injury, Apoptosis, Inflammation, Oxidative stress, rhabdomyolysis, Royal jelly
نویسندگان مقاله | AhmadReza Aminian
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Taghi Khoshniat
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Abolfazl Khajavirad
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Maryam Mahmoudabady
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Hossein Rigi
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Sara Hoseinian
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25512.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات