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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۵، صفحات ۶۴۷-۶۵۴
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عنوان انگلیسی Meloxicam mitigated methylglyoxal-induced glycative stress in rats
چکیده انگلیسی مقاله Objective(s): Glycation is one of the primary underlying processes attributed to senescence and related diseases. No medicine currently targets this harmful manifestation. Drug repurposing is an efficient and cost-effective way of developing drugs. The present study evaluated meloxicam, a clinically used NSAID, for its ability to offer protection against glycative stress.Materials and Methods: Methylglyoxal (MGO; 17.25 mg/kg) was administered for two weeks to create a rat model of glycative stress. Aminoguanidine (AG; 50 mg/kg) and Meloxicam (MEL; 0.15, 0.3, and 0.6 mg/kg) were used as standard and test agents, respectively. Afterward, the cognitive (Morris Water Maze), liver (LFT), and kidney (Creatinine) functioning were evaluated. The expression of genes of interest (TNF-α, RAGE, BACE, Glyoxalase, and VEGF) were estimated (qPCR) in the liver, brain, and kidney along with histopathology (H&E staining). Carboxymethyllysine (CML) levels in rat plasma were evaluated via ELISA.Results: MEL treatment has significantly (P<0.05) protected the MGO-induced cognitive (duration in target quadrant, time taken to get to target quadrant, and the frequency of crossings via platform location), hepatic, and renal impairment. The qPCR data revealed that MEL prevented MGO-induced enhancement in the expression of genes of interest. Additionally, the CML levels were significantly (P<0.005) normalized by concomitant administration of MEL. Histopathological examination did not reveal any remarkable outcomes.Conclusion: MEL has significantly mitigated the rats’ MGO-induced cognitive, liver, and kidney impairments. Hence, it appears to be a potential molecule for repurposing as an antiglycation agent.
کلیدواژه‌های انگلیسی مقاله Advanced Glycation End Products, Carboxymethyllysine, Gene expression, Glycation, Meloxicam, Methylglyoxal
نویسندگان مقاله | Talha Fayyaz
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Ziauddin University, Karachi-75600, Pakistan


| Ghulam Abbas
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Ziauddin University, Karachi-75600, Pakistan


| Hammad Ahmed
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Ziauddin University, Karachi-75600, Pakistan


| Najeeb Khatian
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Ziauddin University, Karachi-75600, Pakistan


| Shumaila Usman
Department of Molecular Medicine, Ziauddin University, Karachi-75600, Pakistan


| Uzair Nisar
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Ziauddin University, Karachi-75600, Pakistan


| Noor Ain
Department of Pharmacology, Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan


| Yamna Khurshid
Department of Molecular Medicine, Ziauddin University, Karachi-75600, Pakistan


| Syed Ali
H.E.J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences, University of Karachi, Karachi-75270, Pakistan
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25604.html
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