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Medical Laboratory Journal، جلد ۱۸، شماره ۴، صفحات ۳۲-۳۵
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عنوان انگلیسی The effects of swimming, cell therapy, and laser therapy on the expression of dynamin-related protein 1, muscle-specific ring finger protein 1, and mitofusin 2 genes in the testes of azoospermic rats
چکیده انگلیسی مقاله
Background: One of the causes of infertility is azoospermia. The present study aimed to investigate the effects of swimming exercise, cell therapy, and laser therapy on the expression of genes involved in mitochondrial dynamics in the testicular tissue of azoospermic rats.
Methods: In this experimental study, 40 rats (6-8-weeks old) were randomly assigned to 8 groups: 1) Healthy control, 2) patient, 3) sham, 4) laser, 5) exercise, 6) cell, 7) cell + laser, and 8) cell + exercise. The azoospermia model was induced using busulfan at a dose of 40 mg. Stem cells were transplanted once into the vas deferens at a concentration of 1000000 cells per rat. One week after cell transplantation, laser therapy was applied in three repetitions throughout the study period, with an interval of once a week, and after wound healing, the rats swam for 30 minutes a day, 5 days a week, for 8 weeks. To investigate the expression of the studied genes, tissue analysis was performed by the real-time polymerase chain reaction (RT-PCR) technique.
Results: Azoospermia significantly reduced the expression of mitofusin 2 (Mfn2) and significantly increased the expression of dynamin-related protein 1 (Drp1) and muscle-specific RING finger protein 1 (Murf1) in testicular tissue. The use of interventional methods increased the expression of Mfn2, and significantly reduced the expression of Murf1.
Conclusion: Based on the findings, the best changes were observed in the exercise + laser group. Therefore, it can be said that in rats using the azoospermia model, the simultaneous use of regular exercise interventions and laser therapy is the most effective.
 
کلیدواژه‌های انگلیسی مقاله Azoospermia, Exercise, Laser therapy, Mitochondrial dynamics, Stem cells
نویسندگان مقاله | Amir Shapoori
Department of Physical Education and Sports Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad katoul, Iran


| Habib Asgharpour
Department of Physical Education and Sports Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad katoul, Iran


| Parvin Farzanegi
Department of Physical Education and Sports Sciences, Sari Branch, Islamic Azad University, Sari, Iran


| Neda Aghaei Bahman Beglou
Department of Physical Education and Sports Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad katoul, Iran
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-1189-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فیزیولوژی ورزشی
نوع مقاله منتشر شده Research Article
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