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Research Journal of Pharmacognosy، جلد ۱۲، شماره ۲، صفحات ۵۷-۶۴
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عنوان انگلیسی Ferula assa-foetida Fruits: Antioxidant Activity, Toxicity Potential and Phytochemical Constituents
چکیده انگلیسی مقاله Background and objectives: Ferula assa-foetida L. is a perennial plant distributed in central and eastern Iran, also in Afghanistan and Pakistan. In the present study, antioxidant activity, toxicity potential and phytochemical constituents of F. assa-foetida fruits were investigated. Methods: Free radical-scavenging activity and general toxicity of the essential oil and different extracts of F. assa-foetida fruits were assessed in DPPH and brine shrimp lethality tests, respectively. Phytochemical analysis of the selected extract was conducted by column chromatography on Silica gel and Sephadex LH-20 columns. GC-MS technique was used for the analysis of fruits essential oil. Results: Among the tested samples, methanol extract showed the highest free radical-scavenging activity with IC50 value of 3.9 ± 0.5 μg/mL, as well as the lowest general toxicity with LD50 value of 45.7 ± 3.1 μg/mL. Phytochemical analysis of the methanol extract resulted in the isolation of seven compounds, namely, luteolin (1), chrysoeriol 7-O-glucoside (2), quercetin 3-O-glucoside (3), chrysoeriol 7-O-rutinoside (4), luteolin 7-O-rutinoside (5), 3,5-di-O-caffeoylquinic acid (6) and luteolin 7-O-glucoside (7). Twenty six compounds were also identified in the fruits essential oil, of which (E)-sec-butyl propenyl disulfide (44.02%) and (Z)-sec-butyl propenyl disulfide (27.68%) were the main compounds. Conclusion: The present study introduces F. assa-foetida fruit as a source of flavonoid, caffeoylquinic acid and disulphide derivatives with known health beneficial effects and suggests it as an appropriate candidate for further pharmacological and toxicological studies.
کلیدواژه‌های انگلیسی مقاله Essential oil,DPPH,caffeoylquinic acid,Flavonoid,Disulfide
نویسندگان مقاله Anita Oyarhossein |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Sina Maskoukian |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Saeed Tavakoli |
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.

Niloofar Zonoubi |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Reza Delnavazi |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی https://www.rjpharmacognosy.ir/article_216249_f3e0b2f8e52d3d63c7f713ff445d0cdd.pdf
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